Renal cell carcinoma (RCC) is the most common malignancy of the kidney and has a poor
prognosis due to its late presentation and resistance to current anticancer drugs. One …

Abstract p 53 and Rb gene mutations are intermediate biomarkers useful for the prediction of
neoplastic progression in bladder cancers. Previously, we have shown that low CYP3A …

This study was designed to analyze the cytochrome P450 isoenzyme mRNA expression
pattern of transitional cell carcinomas of the bladder (N= 19) and normal urothelium (N= 10) …

Abstract Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several
xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine. CYP4B1 allelic …

Abstract Cytochrome P450-isoenzyme, CYP1A1, is responsible for the metabolic activation
of several precarcinogenic environmental chemicals to their carcinogenic intermediates …

Abstract CYP4B1 is a P450 enzyme displaying tissue and species specific regulation. The
rabbit CYP4B1 enzyme exhibits activity towards procarcinogenic aromatic amines. In the …

The predominant inducible cytochrome P450 (CYP) in rat small intestine is CYP1A1, which,
when induced to elevated levels by xenobiotics or dietary constituents, has the potential to …

Previous studies appeared to indicate that CYP1B1 was not constitutively expressed in
mouse liver. In our laboratory, we demonstrated using aromatic hydrocarbon‐responsive …

Abstract Benzo [a] pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH)
found in combustion processes. Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1 …

Our objective was to investigate the expression of different cytochromes P450 3A (CYP3A4,
CYP3A5, and CYP3A7) and P‐glycoprotein (ABCB1) genes along the human large intestine …