Breast cancer is the most common cause of cancer death among women worldwide.
Localized breast cancer can be cured by surgery and adjuvant therapy, but mortality …

Therapeutic targeting of extracellular proteins has attracted huge attention in treating human
diseases. The lysyl oxidases (LOXs) are a family of secreted copper-dependent enzymes …

Background In somatic cancer genomes, delineating genuine driver mutations against a
background of multiple passenger events is a challenging task. The difficulty of determining …

High-grade gliomas are the most threatening brain tumors due to aggressive proliferation
and poor prognosis. Thus, utilizing genetic glioma biomarkers to forecast prognosis and …

Introduction: Hypoxia shapes the tumor microenvironment, modulates distinct cell
populations activity and activates pathological angiogenesis in cancer, where endothelial …

Aims: Glioblastoma (GB) is one of the most aggressive brain tumors. These tumors modify
their metabolism, increasing the expression of glucose transporters, GLUTs, which …

Nonlinear optical imaging (NLOI) has emerged to be a promising tool for bio-medical
imaging in recent times. Among the various applications of NLOI, its utility is the most …

Increasing attention has been given to the tumor microenvironment (TME), which includes
cellular and structural components such as fibroblasts, immune cells, vasculature, and …

Lysyl oxidase (LOX) is involved in vital biological processes such as cell motility, cell
signaling and gene regulation. Deregulation of this protein can contribute to tumor formation …

Heparan sulfate proteoglycans (HSPG s) are the main components of the extracellular
matrix, where they interact with a large number of physiologically important macromolecules …