Complex networks of signaling pathways control the apoptotic response and, therefore, cell
survival. However, these networks converge on a common machinery, of which the caspase …

Changes in ionic homeostasis are early events leading up to the commitment to apoptosis.
Although the direct effects of cations on caspase-3 activity have been examined …

We describe an enzyme-linked immunosorbent assay (ELISA) for quantifying relative
amounts of active caspase 3 in apoptotic cells. Covalent modification of caspase 3 active …

To characterize apoptosis in keloids and the mechanisms responsible for this process, the
expression of activated caspase‐9 and‐3 in fibroblasts obtained from keloids was analyzed …

We have shown previously that the pathways leading to Fas-mediated apoptosis in prostatic
carcinoma cell lines are intact, because apoptosis can be triggered either by Fas ligation …

Adenovirus type 5 E1A has been implicated in mediation of tumor suppression. Preclinical
gene therapy studies have additionally shown that complete growth suppression can be …

BACKGROUND The differential sensitivity of tumor cells to TRAIL‐induced apoptosis may
be mediated by different intracellular inhibitors of apoptosis, and only a few reports have …

Expression of the adenovirus E1A gene in the rat thyroid differentiated cell line PC Cl 3
induces thyrotropin-independent cell growth and impairs differentiation. However, the …

Aims: Studies on cancer biology have shown that overexpression of oncogenes (with or
without functional loss of tumor suppressor genes), which is responsible for the progression …

RhoGDI2, a cytosolic regulator of Rho GTPase, is cleaved during apoptosis in a caspase-3
dependent fashion. By using 2D-gel electrophoresis, mass spectrometry and Western …