[HTML][HTML] Oncolytic virotherapy, updates and future directions

C Fountzilas, S Patel, D Mahalingam - Oncotarget, 2017 - ncbi.nlm.nih.gov
… used systemically, the antiviral immune response can prevent … treatment of colorectal cancer
liver metastasis [72, 73]. The ITu … has antitumor activity, and JX-594 may sensitize tumors to …

[HTML][HTML] Recent advances in oncolytic virus therapy for hepatocellular carcinoma

L Zhu, Y Lei, J Huang, Y An, Y Ren, L Chen… - Frontiers in …, 2023 - frontiersin.org
after injection of JX-594 can enhance the anti-tumor … A phase II clinical trial showed that the
median total survival time of … balance between the anti-tumor immunity and antiviral immunity, …

[HTML][HTML] mRNA therapeutics in cancer immunotherapy

JD Beck, D Reidenbach, N Salomon, U Sahin… - Molecular cancer, 2021 - Springer
… compared to the respective recombinant proteins. This may be … clinical studies explored
mRNA for anti-cancer vaccination, … In a randomized phase II clinical trial (NCT01446731), a DC …

[HTML][HTML] Cancer immunotherapy: the beginning of the end of cancer?

S Farkona, EP Diamandis, IM Blasutig - BMC medicine, 2016 - Springer
from a phase II trial that used a recombinant fusion protein … tolerability, and demonstrated
evidence of antitumor effect. A … are injected locally into the tumor to avoid pre-existing antiviral

A phase II, open-label, randomized trial of durvalumab with olaparib or cediranib in patients with mismatch repair–proficient colorectal or pancreatic cancer

A Hernando-Calvo, M Han, O Ayodele, BX Wang… - … Colorectal Cancer, 2024 - Elsevier
… in gastrointestinal tumors homologous recombination … in prostate cancer cell lines which
include protein transport along … sufficient to elicit anti-tumor immune responses. Of note, results …

[HTML][HTML] Strategies for advanced oncolytic virotherapy: current technology innovations and clinical approaches

Q Ji, Y Wu, A Albers, M Fang, X Qian - Pharmaceutics, 2022 - mdpi.com
… barriers, and antiviral host immunity during its delivery [10]. … has shown enhanced antitumor
activity [32]. Recent published data … phase II studies for patients with colorectal cancer, breast …

[HTML][HTML] Next generation of immune checkpoint therapy in cancer: new developments and challenges

JA Marin-Acevedo, B Dholaria, AE Soyano… - Journal of hematology & …, 2018 - Springer
proteins by malignant cells dysregulates the antitumor … on a phase I/II clinical trial with
metastatic solid malignancies … TTI-621 (SIRPαFc) is a fully recombinant fusion protein consisting of …

Current status of immunotherapy against gastrointestinal cancers and its biomarkers: perspective for precision immunotherapy

S Hazama, K Tamada, Y Yamaguchi… - Annals of …, 2018 - Wiley Online Library
… toxicity profile and promising antitumor activity.53 The FDA … treatment for MSI-H or dMMR
metastatic colorectal cancerantiviral therapy (viral load <100 IU/mL), but antiviral therapy was …

[HTML][HTML] Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future

A Yarahmadi, M Zare, M Aghayari, H Afkhami… - Cell Communication and …, 2024 - Springer
… of new anti-cancer drugs that kill or inactivate cancer cells … Cancer is a disease in which a
cell or group of cells exhibits … to prostate, lung, and colorectal cancers (CRC) in men and lung, …

[HTML][HTML] Combination therapy with oncolytic viruses and immune checkpoint inhibitors in head and neck squamous cell carcinomas: an approach of complementary …

H Dong, M Li, C Yang, W Wei, X He, G Cheng… - Cancer Cell …, 2023 - Springer
… , the recombinant human p53 adenovirus anti-tumor injection (… cancer patients were enrolled
in phase II clinical trial, and … body's antiviral immune response to achieve effective therapy