Semaglutide improves health‐related quality of life versus placebo when added to standard of care in patients with type 2 diabetes at high cardiovascular risk …

E Jódar, M Michelsen, W Polonsky… - Diabetes, Obesity …, 2020 - Wiley Online Library
… The treatment effect of semaglutide versus placebo (unadjusted … of semaglutide on PCS
and MCS qualitatively did not change. … It does not specifically address CV outcomes, but it has …

Reducing cardiovascular outcomes with semaglutide: a metabolic route for a SELECT few

G Liuzzo, C Patrono - 2024 - academic.oup.com
… with overweight or obesity and pre-existing cardiovascular … secondary prevention population
without diabetes, both in terms … Mechanisms of cardiovascular risk reduction by semaglutide

[HTML][HTML] Efficacy and safety of semaglutide for the management of obese patients with type 2 diabetes and chronic heart failure in real-world clinical practice

LM Pérez-Belmonte, J Sanz-Cánovas… - Frontiers in …, 2022 - frontiersin.org
… on HF outcomes focused on patients with HF, in the … cardiovascular outcome trial of
subcutaneous semaglutide in patients with T2D and high cardiovascular risk (23.6% with HF)- no

[HTML][HTML] Effects of semaglutide on albuminuria and kidney function in people with overweight or obesity with or without type 2 diabetes: exploratory analysis from the …

HJL Heerspink, E Apperloo, M Davies, D Dicker… - Diabetes …, 2023 - Am Diabetes Assoc
diabetes and obesity to reduce CV risk (1,12). CV outcomes trials with GLP-1RAs, including
semaglutide, have demonstrated that these agents reduce CV risk and slow kidney function …

[HTML][HTML] Effects of once-weekly semaglutide 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): exploratory analyses of three …

S Verma, M Bhatta, M Davies, JE Deanfield… - …, 2023 - thelancet.com
… In this analysis, CRP reduction was significantly greater with semaglutide compared with
placebo in the STEP 1 and 3 trials of people with overweight or obesity without diabetes. …

[HTML][HTML] Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial

SE Kahn, JE Deanfield, OK Jeppesen, SS Emerson… - Diabetes Care - Am Diabetes Assoc
cardiovascular disease and overweight or obesity but without diabetes, long-term semaglutide
… progression to biochemical diabetes but does not slow glycemic progression over time. …

Semaglutide 2.4 mg for the treatment of obesity: key elements of the STEP trials 1 to 5

RF Kushner, S Calanna, M Davies, D Dicker… - …, 2020 - Wiley Online Library
… trials are investigating semaglutide as a new … obesity because greater WL was observed
with semaglutide than liraglutide ((21)). In the phase 2 trial of semaglutide in adults with obesity, …

Impact of BMI and comorbidities on efficacy of once‐weekly semaglutide: Post hoc analyses of the STEP 1 randomized trial

BM McGowan, A Houshmand‐Oeregaard… - …, 2023 - Wiley Online Library
Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity (SELECT)
cardiovascular outcome trial is examining whether once-weekly sc semaglutide 2.4 …

Effects of semaglutide versus dulaglutide on epicardial fat thickness in subjects with type 2 diabetes and obesity

G Iacobellis, AC Villasante Fricke - Journal of the Endocrine …, 2020 - academic.oup.com
… The roles of semaglutide and dulaglutide, respectively, on EAT are also unknown. Hence, in
… weekly semaglutide and dulaglutide on EAT thickness in overweight/obese type 2 diabetics. …

Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial

FK Knop, VR Aroda, RD do Vale, T Holst-Hansen… - The Lancet, 2023 - thelancet.com
… people with overweight or obesity with or without type 2 diabetes. Oral semaglutide 7 mg
and 14 mg once per day has been approved for the treatment of type 2 diabetes and improves …