[PDF][PDF] Cardiac stem cell therapy and the promise of heart regeneration

JC Garbern, RT Lee - Cell stem cell, 2013 - cell.com
… But as the enthusiasm for cardiac regeneration charges ahead toward clinical translation,
it is crucial for all investigators to maintain objectivity and seek new and complementary ap…

[HTML][HTML] Applications of miRNAs in cardiac development, disease progression and regeneration

JKS Pang, QH Phua, BS Soh - Stem cell research & therapy, 2019 - Springer
… the miRNA dysregulation in congenital heart disease and the … precisely define the appropriate
treatment duration, dosage … be a step towards translating it into clinical therapy, but even …

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions

SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
… Few ideas in medicine have been translated from the … of stem cell therapies in patients with
cardiovascular disease. … of cell-based therapies and proceed toward clinical translation, a …

Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified …

J Bartunek, A Behfar, D Dolatabadi… - Journal of the American …, 2013 - jacc.org
… D, E) Impact of cardiopoietic stem cell therapy (Cell Therapy) on left … Changes in LVEF are
plotted against changes in left … Clinical translation of cardiopoietic stem cell therapy, performed …

Clinical applications of stem cells for the heart

KC Wollert, H Drexler - Circulation research, 2005 - Am Heart Assoc
… The field now is rapidly moving toward intermediate-size, … learned from the translation of
therapeutic angiogenesis into clinical … option for patients with cardiovascular disease. Outcome …

[PDF][PDF] Stem cell therapies in clinical trials: progress and challenges

A Trounson, C McDonald - Cell stem cell, 2015 - cell.com
… funding of translation and clinical stem cell trials for sustained … clinical progress toward
successful therapy for this disease. … the formation of teratomas in these children. These types of …

Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction

A Behfar, S Yamada, R Crespo-Diaz, JJ Nesbitt… - Journal of the American …, 2010 - jacc.org
… hMSC were harvested from a coronary artery disease patient cohort. A recombinant cocktail
… , Abbott Park, Illinois) via nick translation followed by hybridization and denaturation. Frozen …

[HTML][HTML] Clinical trials for stem cell therapies

A Trounson, RG Thakar, G Lomax, D Gibbons - BMC medicine, 2011 - Springer
… in clinical parameters of disability will translate into long-term … immune rejection is moving
towards the clinic but concerns … disorder that affects male children. Preclinical trials showed …

The war against heart failure: the Lancet lecture

E Braunwald - The Lancet, 2015 - thelancet.com
therapy; many short, non-coding RNAs—ie, microRNAs (miRNAs)—block gene expression
and protein translation. … 1), valvular and congenital heart disease, hypertension, and many …

Mesenchymal stem cells: progress toward promise

K Le Blanc, MF Pittenger - Cytotherapy, 2005 - Taylor & Francis
… For instance, MSCs increase the transcription and translation … mesenchymal cells engraft
and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of …