… search for mutations in the human ZP1 gene from the DNA of infertile women, we … Mice
homozygous for an insertional mutation in the ZP3 gene lack a zona pellucida and are infertile…

… mutant female mice have been produced by homologous recombination in embryonic stem
cells. Mutant … fertility of female mice rely on ZP glycoprotein synthesis and the formation of a …

… patients and knock-in mutant mice reveal consistent morphological abnormality … zona
pellucida (ZP) binding analysis unveiled a severe deficiency in sperm-zona association for mutant …

… fertility of homozygous acrosin-KO males. Nine F2 to F4 males homozygous for acrosin
mutations … Interestingly, both acrosin-KO mice and rats showed a delayed sperm penetration of …

… breeding centers and in human fertility clinics to improve the effectiveness of ARTs [186].
Furthermore, since ZP gene mutations are a potential cause of infertility in women, the use of …

… The zona pellucida (ZP) is a thick extracellular coat surrounding the oocyte and … mouse
models revealed a dominantly inherited pattern of heterozygous ZP2 mutation in female infertility …

… mice to explore effective approaches and contents of intervention for individuals carrying
mutations of female infertility … then gently injected under the zona pellucida of the enucleated …

… a zona matrix, and the relative thinness of the zona pellucida … The fertility of Zp1-null mice
indicates that ZP1 is not required … transgenesis, but conditional mutations have proven useful in …

… mice, but no human diseases caused by mutations in BTG4 have previously been reported.
Here, we identified four homozygous mutations … to remove the zona pellucida. After thorough …

… If mutated in transgenic mice or if the cleaving enzyme, ovastacin, is genetically … zona
pellucida and, by genetic ablation, document that this domain is essential for female mouse fertility. …