Interplay of polygenic liability with birth-related, somatic, and psychosocial factors in anorexia nervosa risk: a nationwide study

NM Papini, E Presseller, CM Bulik, K Holde… - Psychological …, 2024 - cambridge.org
BackgroundAlthough several types of risk factors for anorexia nervosa (AN) have been
identified, including birth-related factors, somatic, and psychosocial risk factors, their …

The role of leptin and cortisol in hyperactivity in patients with acute and weight-recovered anorexia nervosa

S Ehrlich, R Burghardt, N Schneider… - Progress in Neuro …, 2009 - Elsevier
INTRODUCTION: In food-restricted rats, leptin as well as corticotropin releasing factor
attenuate semistarvation-induced hyperactivity (SIH). Results from studies in patients with …

Polymorphisms in the leptin (rs7799039) gene are associated with an increased risk of excessive gestational weight gain but not with leptin concentration during …

MC Martins, J Trujillo, DR Farias, G Kac - Nutrition research, 2017 - Elsevier
Single nucleotide polymorphisms (SNPs) in leptin (LEP) and leptin receptor (LEPR) have
been shown to be linked to obesity-related metabolic markers and phenotype. Therefore, we …

Higher leptin levels in Asian Indians than Creoles and Europids: a potential explanation for increased metabolic risk

M Lilja, O Rolandsson, JE Shaw, V Pauvaday… - International journal of …, 2010 - nature.com
Background and purpose: Leptin predicts cardiovascular diseases and type 2 diabetes,
diseases to which Asian Indians are highly susceptible. As a risk marker, leptin's intra …

[HTML][HTML] Leptin and body weight regulation in patients with anorexia nervosa before and during weight recovery1–2

V Haas, S Onur, T Paul, DO Nutzinger… - The American journal of …, 2005 - Elsevier
Background: Leptin has been considered a starvation hormone, but its role in malnourished
patients is unknown. Objective: We aimed to characterize the role of leptin in metabolic …

Leptin in anorexia nervosa

ED Eckert, C Pomeroy, N Raymond… - The Journal of …, 1998 - academic.oup.com
Serum leptin levels are low in untreated anorexia nervosa, but studies of the exact
relationship between leptin and body weight and the impact of refeeding in anorectics are …

Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity

H Yaghootkar, Y Zhang, CN Spracklen, T Karaderi… - Diabetes, 2020 - Am Diabetes Assoc
Leptin influences food intake by informing the brain about the status of body fat stores. Rare
LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity …

Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration

J Hebebrand, WF Blum, N Barth, H Coners… - Molecular …, 1997 - nature.com
Circulating leptin concentrations are known to be low in acute anorexia nervosa (AN), which
is characterized by low weight, amenorrhea and specific psychopathological features. In this …

Hypercaloric diets differing in fat composition have similar effects on serum leptin and weight gain in female subjects with anorexia nervosa

B Mauler, S Dubben, M Pawelzik, D Pawelzik… - Nutrition research, 2009 - Elsevier
Weight regain in subjects with anorexia nervosa is associated with an increase in serum
leptin concentrations that is hypothesized to impair full weight restoration. As diets rich in n-3 …

Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area

LAW Verhagen, MCM Luijendijk, RAH Adan - European …, 2011 - Elsevier
Hyperactivity in anorexia nervosa (AN) is associated with low plasma leptin levels and
negatively impacts on disease outcome. Using an animal model that mimics features of AN …