Yersinia pestis is able to survive and replicate within murine macrophages. However, the
mechanism by which Y. pestis promotes its intracellular survival is not well understood. To …

The ppGpp molecule is part of a highly conserved regulatory system for mediating the
growth response to various environmental conditions. This mechanism may represent a …

To evaluate the role of Yersinia outer proteins (Yops) in conferring protective immunity
against plague, six yop loci from Yersinia pestis were individually amplified by PCR, cloned …

In this paper, we describe for the first time the use of a fully recombinant sub-unit vaccine for
plague. We have compared the protection afforded by the recombinant vaccine against …

We recently identified two virulence-associated small open reading frames (sORF) of
Yersinia pestis, named yp1 and yp2, and null mutants of each individual genes were highly …

Despite the importance of pneumonic plague caused by Yersinia pestis, a few is known
about the interaction between Y. pestis and its host at the molecular level during the …

Ail confers serum resistance in humans and is a critical virulence factor of Y. pestis, the
causative agent of plague. Here, the contribution of Ail for Y. pestis survival in the flea vector …

We determined the role of Yersinia pestis virulence markers in an animal model of
pneumonic plague. Eleven strains of Y. pestis were characterized using PCR assays to …

Insertion mutagenesis with the help of the plasmid pFS23 was used to generate Yersinia
pestis fra mutants. The results of pFra-strain production under non-selective conditions …

Yersinia murine toxin (Ymt) is a phospholipase D encoded on a plasmid acquired by
Yersinia pestis after its recent divergence from a Yersinia pseudotuberculosis progenitor …