14, 15-Epoxyeicosatrienoic acid (EET), a cytochrome P-450 epoxygenase product of
arachidonic acid (AA), reduced PGE2 formation by 40–75% in porcine aortic and murine …

Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates
epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca2+ …

Epoxyeicosatrienoic acids (EETs) are potent vasodilators derived from cytochrome P-450
metabolism of arachidonic acid. The rapid conversion of EETs to their corresponding …

Functional gap junctional communication between vascular cells has been implicated in
ascending dilatation and the cytochrome P-450 (CYP) inhibitor–sensitive and NO-and …

Epoxyeicosatrienoic acids (EETs) are endothelium-derived eicosanoids that activate
potassium channels, hyperpolarize the membrane, and cause relaxation. We tested 19 …

Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases the expression of which is determined by hemodynamic and …

1 In coronary arteries, bradykinin opens endothelial intermediate‐and small‐conductance
Ca2+‐sensitive K+ channels (IKCa and SKCa) and, additionally, releases …

In response to various neurohumoral substances endothelial cells release nitric oxide (NO)
and prostacyclin, and produce hyperpolarization of the underlying vascular smooth muscle …

Epoxyeicosatrienoic acids (EETs) are products of cytochrome P-450 epoxygenase that
possess important vasodilating and anti-inflammatory properties. EETs are converted to the …