Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: beyond leptin and ghrelin

LA Berner, TA Brown, JM Lavender, E Lopez… - Molecular and cellular …, 2019 - Elsevier
The pathophysiology of anorexia nervosa (AN) and bulimia nervosa (BN) are still poorly
understood, but psychobiological models have proposed a key role for disturbances in the …

Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases

MG Guo, DL Reynolds, CE Ang, Y Liu, Y Zhao… - Nature Genetics, 2023 - nature.com
Noncoding variants of presumed regulatory function contribute to the heritability of
neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten …

Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa

V Warrier, R Toro, B Chakrabarti… - Translational …, 2018 - nature.com
Empathy is the ability to recognize and respond to the emotional states of other individuals. It
is an important psychological process that facilitates navigating social interactions and …

The anorexia nervosa genetics initiative (ANGI): overview and methods

LM Thornton, MA Munn-Chernoff, JH Baker… - Contemporary Clinical …, 2018 - Elsevier
Background Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide
significant locus has been identified. We describe methods and procedures for the Anorexia …

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex-and age-dependent

C Hübel, HA Gaspar, JRI Coleman… - Nature …, 2019 - nature.com
Body composition is often altered in psychiatric disorders. Using genome-wide common
genetic variation data, we calculate sex-specific genetic correlations amongst body fat%, fat …

AgRP neurons control compulsive exercise and survival in an activity-based anorexia model

MC Miletta, O Iyilikci, M Shanabrough… - Nature …, 2020 - nature.com
Hypothalamic agouti-related peptide (AgRP) and neuropeptide Y-expressing neurons have
a critical role in driving food intake, but also in modulating complex, non-feeding behaviours …

Conceptualizing body dissatisfaction in eating disorders within a self-discrepancy framework: a review of evidence

EL Lantz, ME Gaspar, R DiTore, AD Piers… - Eating and Weight …, 2018 - Springer
Body dissatisfaction, the negative subjective evaluation of one's body, is associated with
many negative psychological and physical health consequences. One conceptualization of …

Epigenetics in eating disorders: a systematic review

C Hübel, SJ Marzi, G Breen, CM Bulik - Molecular psychiatry, 2019 - nature.com
Eating disorders are complex heritable conditions influenced by both genetic and
environmental factors. Given the progress of genomic discovery in anorexia nervosa, with …

Are trans diagnostic models of eating disorders fit for purpose? A consideration of the evidence for food addiction

J Treasure, M Leslie, R Chami… - European Eating …, 2018 - Wiley Online Library
Explanatory models for eating disorders have changed over time to account for changing
clinical presentations. The transdiagnostic model evolved from the maintenance model …

Examination of the shared genetic basis of anorexia nervosa and obsessive–compulsive disorder

Z Yilmaz, M Halvorsen, J Bryois, D Yu… - Molecular …, 2020 - nature.com
Anorexia nervosa (AN) and obsessive–compulsive disorder (OCD) are often comorbid and
likely to share genetic risk factors. Hence, we examine their shared genetic background …