… The ion channel for the influenza A virus, but not influenza B virus, is inhibited by the antiviral
… from influenza A virus, is the target for action of the antiviral drug amantadine. Thus, these …

… Amantadine and rimantadine both target the M2 protein and are specific for influenza A
virus. By inhibiting M2 ion channel activity, they block acidification of the incoming virus particle …

… assemble to form ion channel structures and was … of antiviral targets, with an increasing
number of such proteins described and characterized, and the success of using host ion channel …

… led to the development of curative antiviral therapy. Moreover, … inhibitors for antagonizing p7
ion channel/pore-like activity. … disruption of ionic gradients across target membranes thereby …

… Here, we review entry of this important pathogen into target cells, an essential process by …
the first essential step of virus replication and is an ideal target to block infection efficiently. …

… ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the
antiviral … of proton conductance of the viral ion channels are described and the review makes a …

… were the adamantanes or M2 ion channel inhibitors and the … and they act by blocking the
M2 ion channel activity (for influenza A … function would be a good antiviral target [25]. However, …

… ion channel (M2) that is the target of the adamantane family of drug inhibitors. Two recently
published studies relating to adamantane binding of the M2 ion channel … of antiviral drugs …

… 7 indicated that the target of antiviral action is the hydropho… ion channel activity. The
concentrations of the drug used to … in testing the associated ion channel activity of MP proteins …

… ion channel, or “viroporin,” whose essential functions represent a clinically proven class of
antiviral target … Specific drug-protein interactions validate an allosteric site on the channel …