… We then propose a path forward by highlighting several hypotheses and novel strategies
to maximize the potential benefit that ADCs can provide to patients with cancer. …

… PP2A as a novel strategy for the treatment of prostate cancer. … were adjusted for multiple
hypotheses testing using the p.… been largely ignored for drug development because of their …

… To assist the cancer drug discovery and development … types of cancer, notably breast and
prostate cancer and melanoma 170 … These studies offer a provocative translational hypothesis, …

… , in the form of novel trial designs or modelling strategies, to … patients with metastatic
castration-resistant prostate cancer … secondary analyses to test prespecified hypotheses can …

… -resistant prostate cancer. We review clinical trials and survival benefit for these therapies
and assess how the understanding of the disease shifted as these therapies were developed. …

… The biological definition of oligometastatic prostate cancer is open to interpretation as is the
entire concept that this is a prognostic and therapeutically distinct subset of patients that falls …

… biological mechanism is described as “prostate stagnation hypothesis”, which involves the
prostatic … This information will provide an opportunity for the development of novel targeted …

… the discovery of many basic biological processes, they often fail to provide an adequate platform
for drug discovery … potential of novel lead compounds and new target hypotheses. ECM, …

… drug discovery because it provides a novel way to explore old … Hypothesis-driven strategies
for drug repurposing can … Metformin Type II diabetes Advanced prostate cancer Inhibition of …

… To test this hypothesis, we first compared the level of cGMP in … sGC may provide a novel
strategy to treat TMPRSS2-ERG-… calculated based on at least 3 biological repeats. Student’s t-…