The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine

P Kumar, S Kandoi, R Misra, S Vijayalakshmi… - Cytokine & growth factor …, 2019 - Elsevier
… potential for indications such as osteoarthritis, spinal cord injury, cardiovascular disease,
gastric … of MSC-CM, much needs to be done to translate the promise to the clinic. Central to the …

Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy

K Hirai, D Ousaka, Y Fukushima, M Kondo… - Science translational …, 2020 - science.org
… in a porcine model of DCM and translate the preclinical results into this patient population. A
… of stem cells has expanded the possibilities for myocardial repair to treat children with CHD

Influence of carrier cells on the clinical outcome of children with neuroblastoma treated with high dose of oncolytic adenovirus delivered in mesenchymal stem cells

GJ Melen, L Franco-Luzón, D Ruano… - Cancer letters, 2016 - Elsevier
… results on expression levels translated into functional differences. We first studied whether
CELYVIR products used for the patients were able to migrate toward chemotactic stimuli. We …

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

JPA Ioannidis, BYS Kim, A Trounson - Nature biomedical engineering, 2018 - nature.com
… Pluripotent stem cells, either embryonic stem cells or induced pluripotent stem cells, can
be directed towards the ventral neural floor plate lineage (PAX6 – ) and multiplied as …

[PDF][PDF] Mettl1/Wdr4-mediated m7G tRNA methylome is required for normal mRNA translation and embryonic stem cell self-renewal and differentiation

S Lin, Q Liu, VS Lelyveld, J Choe, JW Szostak… - Molecular cell, 2018 - cell.com
… the m 7 G tRNA methylome in mouse embryonic stem cells (mESCs). A subset of 22 tRNAs
… function, ribosome pausing, and mRNA translation. Translation of cell cycle genes and those …

[HTML][HTML] Biological scaffolds for congenital heart disease

AG Harris, T Salih, MT Ghorbel, M Caputo, G Biglino… - Bioengineering, 2023 - mdpi.com
… , most of them failed to be successfully translated in this life-… in paediatric CHD treatment,
warning against the application … primary cell types have a limited lifespan, stem cells are self-…

Stem cell therapy for neurological disorders

M Alessandrini, O Preynat-Seauve… - South African Medical …, 2019 - journals.co.za
… -like cells have also been developed and translated for clinical … The authors reported an
overall trend towards improvement, but … stem cells to improve symptoms in children with autism. …

Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2

S Tahmasebi, SM Jafarnejad, IS Tam… - Proceedings of the …, 2016 - National Acad Sciences
stem cells (ESCs) maintain a low translation rate; therefore control of mRNA translation is …
expression directs differentiation of mESCs toward cardiovascular lineages. Examination of the …

[HTML][HTML] Bioprocessing of mesenchymal stem cells and their derivatives: toward cell-free therapeutics

J Phelps, A Sanati-Nezhad, M Ungrin… - Stem Cells …, 2018 - hindawi.com
… address some of the key challenges for the clinical translation of MSCbased therapies. …
sis in coronary heart disease patients; however, such trials have not been able to match the …

Stem cells in neonatal diseases: An overview

S Chaubey, V Bhandari - Seminars in Fetal and Neonatal Medicine, 2022 - Elsevier
… results that hold promise for translation to the bedside. The … first step towards clinical
application of MSCs to treat PAIS. … therapeutic method for treating children with severe CP [125]. …