The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine
… potential for indications such as osteoarthritis, spinal cord injury, cardiovascular disease,
gastric … of MSC-CM, much needs to be done to translate the promise to the clinic. Central to the …
gastric … of MSC-CM, much needs to be done to translate the promise to the clinic. Central to the …
Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy
K Hirai, D Ousaka, Y Fukushima, M Kondo… - Science translational …, 2020 - science.org
… in a porcine model of DCM and translate the preclinical results into this patient population. A
… of stem cells has expanded the possibilities for myocardial repair to treat children with CHD …
… of stem cells has expanded the possibilities for myocardial repair to treat children with CHD …
Influence of carrier cells on the clinical outcome of children with neuroblastoma treated with high dose of oncolytic adenovirus delivered in mesenchymal stem cells
GJ Melen, L Franco-Luzón, D Ruano… - Cancer letters, 2016 - Elsevier
… results on expression levels translated into functional differences. We first studied whether
CELYVIR products used for the patients were able to migrate toward chemotactic stimuli. We …
CELYVIR products used for the patients were able to migrate toward chemotactic stimuli. We …
How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation
… Pluripotent stem cells, either embryonic stem cells or induced pluripotent stem cells, can
be directed towards the ventral neural floor plate lineage (PAX6 – ) and multiplied as …
be directed towards the ventral neural floor plate lineage (PAX6 – ) and multiplied as …
[PDF][PDF] Mettl1/Wdr4-mediated m7G tRNA methylome is required for normal mRNA translation and embryonic stem cell self-renewal and differentiation
… the m 7 G tRNA methylome in mouse embryonic stem cells (mESCs). A subset of 22 tRNAs
… function, ribosome pausing, and mRNA translation. Translation of cell cycle genes and those …
… function, ribosome pausing, and mRNA translation. Translation of cell cycle genes and those …
[HTML][HTML] Biological scaffolds for congenital heart disease
AG Harris, T Salih, MT Ghorbel, M Caputo, G Biglino… - Bioengineering, 2023 - mdpi.com
… , most of them failed to be successfully translated in this life-… in paediatric CHD treatment,
warning against the application … primary cell types have a limited lifespan, stem cells are self-…
warning against the application … primary cell types have a limited lifespan, stem cells are self-…
Stem cell therapy for neurological disorders
M Alessandrini, O Preynat-Seauve… - South African Medical …, 2019 - journals.co.za
… -like cells have also been developed and translated for clinical … The authors reported an
overall trend towards improvement, but … stem cells to improve symptoms in children with autism. …
overall trend towards improvement, but … stem cells to improve symptoms in children with autism. …
Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2
S Tahmasebi, SM Jafarnejad, IS Tam… - Proceedings of the …, 2016 - National Acad Sciences
… stem cells (ESCs) maintain a low translation rate; therefore control of mRNA translation is …
expression directs differentiation of mESCs toward cardiovascular lineages. Examination of the …
expression directs differentiation of mESCs toward cardiovascular lineages. Examination of the …
[HTML][HTML] Bioprocessing of mesenchymal stem cells and their derivatives: toward cell-free therapeutics
… address some of the key challenges for the clinical translation of MSCbased therapies. …
sis in coronary heart disease patients; however, such trials have not been able to match the …
sis in coronary heart disease patients; however, such trials have not been able to match the …
Stem cells in neonatal diseases: An overview
S Chaubey, V Bhandari - Seminars in Fetal and Neonatal Medicine, 2022 - Elsevier
… results that hold promise for translation to the bedside. The … first step towards clinical
application of MSCs to treat PAIS. … therapeutic method for treating children with severe CP [125]. …
application of MSCs to treat PAIS. … therapeutic method for treating children with severe CP [125]. …