Methods Colonic biopsies were obtained from patients with active CD or UC. Biopsies were
made in inflammatory and non-inflammatory mucosa for both conditions. Patients with …

An imbalance of immunoregulatory factors and/or cells contributes to uncontrolled mucosal
T cell activation and inflammation in Crohn's disease (CD). Bioactive interleukin (IL)-18 has …

Background and aims: Interleukin-12 (IL-12), a p35/p40 heterodimer, plays a pivotal role in
the immune response in Crohn's disease (CD). Since IL-12 p40 dimers act as IL-12 …

Abstract Interleukin (IL)-12 p35/p40 is a heterodimeric cytokine that plays an important role
in T helper (Th) cell polarization and Th1 T-cell differentiation. Recent findings have shown …

Background IL-23/TH17 inflammatory responses are regarded as central to the
pathogenesis of inflammatory bowel disease, but clinically IL-17A antibodies have shown …

Gut inflammation occurring in patients with Crohn's disease and patients with ulcerative
colitis has been traditionally associated with an exaggerated Th1 or Th2 cell response …

Immune phenomena are believed to play a key role in the pathogenesis of tissue damage in
Crohn's disease and ulcerative colitis. 1 2 Although some of the immunological …

Background and Aim. Interleukin-21 (IL-21) is primarily a T cell-derived cytokine; it is
upregulated in patients with Crohn's Disease (CD) and could be a potential new therapeutic …