Chromosomal regions with meiotic drivers exhibit biased transmission (> 50%) over their
competing homologous chromosomal region. These regions often have two prominent …

Meiosis is the specialized cell division during which parental genomes recombine to create
genotypically unique gametes. Despite its importance, mammalian meiosis cannot be …

Meiotic drivers are selfish genes that bias their transmission into gametes, defying
Mendelian inheritance. Despite the significant impact of these genomic parasites on …

A hallmark of meiosis is the rearrangement of parental alleles to ensure genetic diversity in
the gametes. These chromosome rearrangements are mediated by the repair of …

mei1 (meiosis defective 1) is the first meiotic mutation in mice derived by phenotype-driven
mutagenesis. It was isolated by using a novel technology in which embryonic stem (ES) cells …

Theory predicts that selfish genetic elements that increase their transmission are prone to
originate on sex-‐chromosomes but create strong selective pressure to evolve suppressors …

Selfishly evolving centromeres bias their transmission by exploiting the asymmetry of female
meiosis and preferentially segregating to the egg. Such female meiotic drive systems have …

Asymmetric division in female meiosis creates selective pressure favoring selfish
centromeres that bias their transmission to the egg. This centromere drive can explain the …

One approach to understanding the process of speciation is to characterize the genetic
architecture of post-zygotic isolation. As gene regulation requires interactions between loci …

Meiotic recombination is a process that increases genetic diversity and is fundamental for
sexual reproduction. Determining by which mechanisms genetic variation is generated and …