Pain is an inherent component of inflammation often accompanying immune response. A
large spectrum of molecules released within the inflamed tissue induces pain by stimulating …

Endomorphins (EMs) are endogenous selective μ-opioid receptor agonists. Their role in
inflammatory pain has not been fully elucidated. Here we examine peripheral …

Immune cell-derived opioid peptides can activate opioid receptors on peripheral sensory
nerves to inhibit inflammatory pain. The intrinsic mechanisms triggering this neuroimmune …

Opioid receptors and their ligands produce powerful analgesia that is effective in
perioperative period and chronic pain managements accompanied with various side effects …

Exogenous κ-opioid agonists have been shown to produce peripheral antinociceptive
effects in inflamed tissue. This study sought to determine whether endogenous κ-receptor …

Opioid addicts are more likely to present with infections suggesting opioids are immune
modulators. The potential sites/mechanism (s) for this modulation are controversial and on …

In painful inflammation, exogenous as well as endogenous corticotropin-releasing hormone
(CRH) can release opioid peptides (mainly β-endorphin) from various types of immune cells …

The stress of surgery is characterized by an inflammatory response with immune
suppression resulting from many factors, including the type of surgery and the kind of …

JUSTIFICATIVA E OBJETIVO: O crescente uso de opioides para o tratamento da dor é uma
realidade em vários países. Com o aumento do uso aparecem questionamentos menos …