Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy

J Xie, Z Fan, Y Li, Y Zhang, F Yu, G Su… - International journal of …, 2018 - Taylor & Francis
Aim We designed acid-labile methotrexate (MTX) targeting prodrug self-assembling
nanoparticles loaded with curcumin (CUR) drug for simultaneous delivery of multi …

Recent advances in curcumin-loaded biomimetic nanomedicines for targeted therapies

F Lei, P Li, T Chen, Q Wang, C Wang, Y Liu… - Journal of Drug Delivery …, 2023 - Elsevier
Curcumin shows excellent anti-inflammatory and anti-tumor activities, but its solubility,
stability, and bioavailability are poor. Nanoparticle delivery systems can be used to enhance …

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

I Ahmad, S Ahmad, A Ahmad… - Cell Biochemistry …, 2024 - Wiley Online Library
Curcumin is a natural compound derived from turmeric and can target malignant tumor
molecules involved in cancer propagation. It has potent antioxidant activity, but its …

Curcumin-based nanomedicines: A promising avenue for brain neoplasm therapy

M Banazadeh, B Behnam, NA Ganjooei… - Journal of Drug Delivery …, 2023 - Elsevier
Brain tumor ranks as the tenth most common cause of death among individuals with cancer
globally, and those diagnosed with this condition continue to experience unfavorable …

Design of curcumin loaded carbon nanodots delivery system: Enhanced bioavailability, release kinetics, and anticancer activity

DM Arvapalli, AT Sheardy, K Allado… - ACS Applied Bio …, 2020 - ACS Publications
Despite the potential health benefits of curcumin, such as antioxidant, anticancer, anti-
inflammatory, and antimicrobial properties, its usage is limited by poor bioavailability and …

Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment

M Akrami, M Khoobi, M Khalilvand-Sedagheh… - RSC Advances, 2015 - pubs.rsc.org
Biocompatible multi-layer iron oxide magnetic nanoparticles (MNPs) for drug delivery
applications with increased loading capacity, sustained sensitive release profile, and high …

Synergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer

F Gong, JC Ma, J Jia, FZ Li, JL Wu, S Wang, X Teng… - Drug Delivery, 2021 - Taylor & Francis
Abstract Curcumin (1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) is a
potent anticancer drug with versatile biological activities, while the clinical translation of …

Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration

Y Huang, L Hu, S Huang, W Xu, J Wan… - International Journal …, 2018 - Taylor & Francis
Background The main objective of this study was to develop novel BSA nanoparticles (BSA
NPs) for improving the bioavailability of curcumin as an anticancer drug, and those BSA NPs …

Curcumin delivery by methoxy polyethylene glycol–poly (caprolactone) nanoparticles inhibits the growth of C6 glioma cells

J Shao, D Zheng, Z Jiang, H Xu, Y Hu… - Acta Biochim Biophys …, 2011 - academic.oup.com
As a potential anticancer agent, curcumin (Cum) has been reported for its chemopreventive
and chemotherapeutic activity in a series of cancers through influencing cell cycle arrest …

Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models

AL Luss, DV Bagrov, AV Yagolovich, EV Kukovyakina… - Pharmaceutics, 2023 - mdpi.com
Curcumin attracts huge attention because of its biological properties: it is antiproliferative,
antioxidant, anti-inflammatory, immunomodulatory and so on. However, its usage has been …