Calcimimetics increase the sensitivity of the calcium-sensing receptor (CaR) to circulating
serum calcium, reducing the secretion of PTH and the serum calcium concentration. We …

A homology model for the human calcium sensing receptor (hCaR) transmembrane domain
utilizing bovine rhodopsin (bRho) structural information was derived and tested by docking …

The calcium‐sensing receptor (CaS receptor) plays a pivotal role in extracellular calcium
homeostasis, and germline loss‐of‐function and gain‐of‐function mutations cause familial …

The two main neurotransmitters, glutamate and GABA, as well as calcium ions, sweet taste
molecules and some pheromones, act on class-C G-protein-coupled receptors (GPCRs) …

Calcium is a crucial second messenger in the cardiovascular system. However, calcium may
also be an extracellular first messenger through a G‐protein‐coupled receptor that senses …

Abstract▲ Oral cinacalcet hydrochloride (HCl)[Sensipar®, Mimpara®] is the first in a new
class of therapeutic agents, the calcimimetics, and has a novel mechanism of action. It …

Calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor (GPCR) that plays
an important role in calcium homeostasis and parathyroid hormone secretion. Here, we …

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled
receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It …

Numerous in vivo functional studies have indicated that the dimeric extracellular domain
(ECD) of the CaSR plays a crucial role in regulating Ca 2+ homeostasis by sensing Ca 2+ …

Gprotein-coupled receptors (GPCRs) serve as cellular sensors for a broad range of
stimulants including photons, odorants, hormones, neurotransmitters, and ions. The studies …