Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models
Recent advances indicate that maintaining a balanced level of autophagy is critically
important for neuronal health and function. Pathologic dysregulation of macroautophagy has …
important for neuronal health and function. Pathologic dysregulation of macroautophagy has …
Autophagy negatively regulates early axon growth in cortical neurons
BK Ban, MH Jun, HH Ryu, DJ Jang… - … and cellular biology, 2013 - Taylor & Francis
Neurite growth requires neurite extension and retraction, which are associated with protein
degradation. Autophagy is a conserved bulk degradation pathway that regulates several …
degradation. Autophagy is a conserved bulk degradation pathway that regulates several …
Controlling the mass action of α‐synuclein in Parkinson's disease
Parkinson's disease (PD) is an age‐related neurodegenerative disease with unknown
etiology. Growing evidence from genetic, pathologic, animal modeling, and biochemical …
etiology. Growing evidence from genetic, pathologic, animal modeling, and biochemical …
Autophagy in acute brain injury: feast, famine, or folly?
CM Smith, Y Chen, ML Sullivan, PM Kochanek… - Neurobiology of …, 2011 - Elsevier
In the central nervous system, increased autophagy has now been reported after traumatic
brain and spinal cord injury, cerebral ischemia, intracerebral hemorrhage, and seizures …
brain and spinal cord injury, cerebral ischemia, intracerebral hemorrhage, and seizures …
Autophagic flux determination in vivo and ex vivo
L Esteban-Martínez, P Boya - Methods, 2015 - Elsevier
Autophagy is a highly dynamic process that mediates the degradation of cellular
constituents inside lysosomes. It is characterized by the formation of autophagosomes …
constituents inside lysosomes. It is characterized by the formation of autophagosomes …
[HTML][HTML] Multifaceted deaths orchestrated by mitochondria in neurones
Neurones undergo diverse forms of cell death depending on the nature and severity of the
stress. These death outcomes are now classified into various types of programmed cell …
stress. These death outcomes are now classified into various types of programmed cell …
Loss of G as6 and A xl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone …
Abstract The TAM (Tyro3, Axl, and MerTK) family of receptor tyrosine kinases (RTKs) and
their ligands, Gas6 and ProS1, are important for innate immune responses and central …
their ligands, Gas6 and ProS1, are important for innate immune responses and central …
Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes
SB Jänen, H Chaachouay, C Richter‐Landsberg - Glia, 2010 - Wiley Online Library
A common pathway underlying a variety of neurodegenerative disorders is the aggregation
and deposition of misfolded proteins. Proteasomal inhibition has been demonstrated to …
and deposition of misfolded proteins. Proteasomal inhibition has been demonstrated to …
Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15
C Vantaggiato, C Crimella, G Airoldi, R Polishchuk… - Brain, 2013 - academic.oup.com
Hereditary spastic paraparesis type 15 is a recessive complicated form of the disease
clinically characterized by slowly progressive spastic paraparesis and mental deterioration …
clinically characterized by slowly progressive spastic paraparesis and mental deterioration …
Abnormal autophagy, ubiquitination, inflammation and apoptosis are dependent upon lysosomal storage and are useful biomarkers of mucopolysaccharidosis VI
A Tessitore, M Pirozzi, A Auricchio - Pathogenetics, 2009 - Springer
Background Lysosomal storage diseases are characterized by intracellular accumulation of
metabolites within lysosomes. Recent evidence suggests that lysosomal storage impairs …
metabolites within lysosomes. Recent evidence suggests that lysosomal storage impairs …