TGF-β-regulated collagen type I accumulation: role of Src-based signals
R Mishra, L Zhu, RL Eckert… - … of Physiology-Cell …, 2007 - journals.physiology.org
… Similarly, targeting bioactive TGF-β to the mouse lung provokes … of PKCδ in Src activation,
we transduced mesangial cells with … Src by a PKCδ-dependent mechanism, then inhibition of …
we transduced mesangial cells with … Src by a PKCδ-dependent mechanism, then inhibition of …
Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets
… Still ongoing for diabetic kidney disease. Previous study … TGF-β1 production by macrophages
and mesangial cells, and … EGFR can also be transactivated indirectly by AngII via Src …
and mesangial cells, and … EGFR can also be transactivated indirectly by AngII via Src …
[HTML][HTML] YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α …
X Li, TK Ma, M Wang, XD Zhang, TY Liu… - Frontiers in …, 2023 - frontiersin.org
… and inducing fibrosis in diabetic kidney disease (DKD). The … EGFR in high glucose-induced
HRMCs and diabetic db/db … high glucose-induced human glomerular mesangial cells and …
HRMCs and diabetic db/db … high glucose-induced human glomerular mesangial cells and …
ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice
… prominent feature of diabetic nephropathy that contributes to … in a reduction of glucose-induced
Nox4 protein expression by … in mesangial cells suggest that the increase in collagen I and …
Nox4 protein expression by … in mesangial cells suggest that the increase in collagen I and …
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis
J Zeng, L Liang, R Chen, C Li, L Pan, M Wen… - European Journal of …, 2023 - Elsevier
… the main pathological change of diabetic nephropathy (DN). Fraxin… inhibited inflammation
to ameliorate diabetic RIF by suppressing EGFR/c-Src/NF-κB axis activation in both db/db mice …
to ameliorate diabetic RIF by suppressing EGFR/c-Src/NF-κB axis activation in both db/db mice …
[HTML][HTML] Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy
J Pan, M Shi, L Li, J Liu, F Guo, Y Feng, L Ma… - Biomedicine & …, 2019 - Elsevier
… uricase inhibitor, as well as adenine to make HN mice model … Administration of PTE prevented
the progression of kidney … of Smads via the transactivation of Src kinase or STAT3 protein […
the progression of kidney … of Smads via the transactivation of Src kinase or STAT3 protein […
High glucose enhances the aggressiveness of lung adenocarcinoma via activating epidermal growth factor receptor/signal transducer and activator of transcription 3 …
S Sorin, Y Zhou, K Thithuan, K Khawkhiaw… - The Journal of …, 2023 - Elsevier
… in people with DM could transactivate EGFR in vitro by … The inhibitory effects of erlotinib
on high glucose induced … under high glucose in mesangial cells without the requirement …
on high glucose induced … under high glucose in mesangial cells without the requirement …
[HTML][HTML] Recent advances in pharmacological diversification of Src family kinase inhibitors
P Negi, RS Cheke, VM Patil - Egyptian Journal of Medical Human Genetics, 2021 - Springer
… Src kinase activation that causes transactivation of EGFR. … high glucose-induced diabetic
complications, the role of Src … Src as a novel therapeutic target for diabetic neuropathy. In STZ-…
complications, the role of Src … Src as a novel therapeutic target for diabetic neuropathy. In STZ-…
[HTML][HTML] ADAMs family in kidney physiology and pathology
H Zhu, J Wang, W Nie, I Armando, F Han - EBioMedicine, 2021 - thelancet.com
… injury, diabetic kidney disease, polycystic kidney disease, … changes, activators or inhibitors.
After biosynthesis in the … , glomerular endothelial cells interact with mesangial cells and …
After biosynthesis in the … , glomerular endothelial cells interact with mesangial cells and …
[HTML][HTML] Src inhibition attenuates liver fibrosis by preventing hepatic stellate cell activation and decreasing connective tissue growth factor
HY Seo, SH Lee, JH Lee, YN Kang, JS Hwang… - Cells, 2020 - mdpi.com
… of type I collagen, αSMA, and CTGF in mouse liver tissues. … Formalin-fixed and paraffin-embedded
tissue blocks were … activation of SRC family kinases in the mouse model of TAA-…
tissue blocks were … activation of SRC family kinases in the mouse model of TAA-…