Scanning for therapeutic targets within the cytokine network of idiopathic inflammatory myopathies

B De Paepe, J Zschüntzsch - International Journal of Molecular Sciences, 2015 - mdpi.com
cytokines in the immune cell infiltration in IIM, and summarize common and emerging
therapeutic approaches that display potential for the manipulation of cytokine networks in patients. …

T helper type-2 cytokine responses: potential therapeutic targets

AG Jarnicki, PG Fallon - Current Opinion in Pharmacology, 2003 - Elsevier
… diseases, various therapeutic strategies that … novel therapeutic targets. In this review, we
examine recent developments in the manipulation of Th2 responses that might have therapeutic

[PDF][PDF] Review of prominent cytokines as superior therapeutic targets for moderate-to-severe atopic dermatitis

Z Hassan, E Luvsannyam, D Patel, S Nukala… - Cureus, 2020 - cureus.com
… information to expands upon cytokines presented in this article as well as discuss other
cells and players that may prove to be superior targets than the cytokines discussed. With …

Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets

V Yadav, F Varum, R Bravo, E Furrer, D Bojic… - Translational …, 2016 - Elsevier
… coding for inflammatory cytokines. Polymorphism in the G(-308)A and C(-511)T site of the
TNF-α and IL-1β promotor regions respectively leads to impaired cytokine expression and has …

[引用][C] Role of inflammatory cytokines in the pathogenesis of rheumatoid arthritis and novel therapeutic targets

S Shehu, AU Kurya, DC Sharma - Asian Journal of Immunology, 2020

[HTML][HTML] Averting inflammation by targeting the cytokine environment

M Kopf, MF Bachmann, BJ Marsland - Nature Reviews Drug Discovery, 2010 - nature.com
… of cytokine networks may lead to the development of highly specific therapeutics targeting
… Rather than blocking early pleiotropic cytokines, future success may lie in the combined …

[HTML][HTML] Leukemia stem cells and microenvironment: biology and therapeutic targeting

MY Konopleva, CT Jordan - Journal of clinical oncology, 2011 - ncbi.nlm.nih.gov
Therapeutic targeting leukemic stem cell (LSC) niche interactions. Cytokines, chemokines,
and the … The therapeutic strategies designed to target the LSC within their surrounding …

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40

K Sugamura, N Ishii, AD Weinberg - Nature Reviews Immunology, 2004 - nature.com
… More recently, second-generation immunotherapies targeting cytokines or their receptors
that are responsible for disease pathogenesis have been established, but the consequences …

Synergy and specificity in induction of gene activity by proinflammatory cytokines: potential therapeutic targets

J Spink, J Cohen - Shock, 1997 - journals.lww.com
… The proinflammatory cytokine cascade is involved in both the normal immune … novel
therapeutic drugs for the selective manipulation of these disease processes. Such potential targets

Therapeutics targeting the innate immune system

RJ Ulevitch - Nature Reviews Immunology, 2004 - nature.com
… In this review, I discuss interesting drug targets that have emerged from recent studies of
TLRs and/or NOD proteins, without considering as targets the numerous downstream cytokines