For 6 months, male Wistar rats received an iodine deficient diet (LID), with propylthiouracil
(PTU) for the last 2 months. At the end of this treatment (day 0), a daily iodide intake of 20 μg …

Type 3 iodothyronine deiodinase (D3) is the physiologic inactivator of thyroid hormones,
catalyzing the innerring deiodination of thyroxine (T4) to reverse triiodothyronine (rT3) and …

Thyroid hormones regulate brain development and function through the control of gene
expression, mediated by binding of T3 to nuclear receptors. Brain T3 concentration is tightly …

The thyroid status of severely iodine-deficient rats was assessed by measurement of the
resting metabolic rate (RMR) and liver mitochondrial α-glycerophosphate dehydrogenase (α …

Mice with one thyroid hormone receptor (TR) α-1 allele encoding a dominant negative
mutant receptor (TRα1PV/+) have persistently elevated serum T3 levels (1.9-fold above …

Iodine deficiency induces multiple intrathyroidal autoregulatory changes leading to an
increased triiodothyronine (T3) production and secretion, at the expense of thyroxine (T4). It …

Deiodinases modify the biological activity of thyroid hormone (TH) molecules, ie, they may
activate thyroxine (T4) to 3, 5, 3′-triiodothyronine (T3), or they may inactivate T3 to 3, 3 …

Lactating rat mammary gland expresses a deiodinating activity that, on the basis of kinetic
characteristics, corresponds to the so-called 5′-deiodinase type I (D1). In the present study …

During pregnancy maternal thyroid hormones are of great importance for normal
development of the central nervous system of the fetus. Iodine deficiency of the mother carl …

The kinetics of type III iodothyronine deiodinase (5-D) in rat placenta and brain and the role
of phospholipids in enzyme activity were determined. Pregnant Sprague-Dawley rats were …