Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, is overexpressed in
many types of malignant tumors, which in turn may stimulate tumor growth and protect …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

Non-steroidal anti-inflammatory drugs act by inhibiting cyclooxigenase enzyme in the
plasma membrane predominantly. Nowadays many researchers have observed a great …

The cyclooxygenase-2 (COX-2) protein is highly expressed in a variety of human cancers
and has been reported to promote tumor growth. Non-steroidal anti-inflammatory drugs such …

In recent years, a combination of two demographic phenomena, an increase in the number
of older people in the population and an increase in the incidence of lung cancer with age …

The finding that cyclooxygenase-2 (COX-2) is over-expressed and plays an important role in
carcinogenesis in gastrointestinal (GI) cancers including esophagus, gastric and colorectal …

Background: Glioblastoma multiforme (GBM) is a high-grade primary brain tumor that is
refractory to current forms of treatment. In cell studies, the growth rate of GBM cells correlates …

Cyclooxygenase (COX) is an enzyme complex that plays an important role in the conversion
of arachidonic acid to prostaglandins. Prostaglandins are essential modulators of signal …

The COX-2 protein is frequently overexpressed in human malignant gliomas. This
expression has been associated with their aggressive growth characteristics and poor …

Abstract Cyclooxygenase‐2 (COX‐2), an enzyme that catalyzes the synthesis of
prostaglandins, is overexpressed in a variety of premalignant and malignant conditions …