The objective of this study was to investigate BRD4 expression in patients with essential
hypertension (EH) and its effects on the blood pressure in spontaneously hypertensive …

Renal fibrosis was a chronic and progressive process affecting kidneys in chronic kidney
disease (CKD), regardless of cause. Although no effective targeted therapy yet existed to …

Diabetic cardiomyopathy is a cascade of complex events leading to eventual heart failure in
diabetes. JQ1, one of Bromodomain and extra-terminal domain (BET) protein inhibitors, has …

Renal ischemia reperfusion injury (IRI) is associated with inflammation, including neutrophil
infiltration that exacerbates the initial ischemic insult. The molecular pathways involved are …

Macrophages play critical roles in the first-line immune defense against airway infections
caused by Pseudomonas aeruginosa (PA). The redox-active phenazine-pyocyanin (PCN) …

Fabry disease (FD) is a rare X‐linked disorder of lipid metabolism, characterized by the
accumulation of globotriaosylceramide (Gb3) due to defective the lysosomal enzyme, α …

Oxidative stress and fibrosis may accelerate the progression of chronic kidney disease
(CKD). DKK3 is related to regulating renal fibrosis and CKD. However, the molecular …

Crohn's disease (CD) is a lifelong inflammatory bowel disease with a rapidly rising
incidence in the pediatric population. A common complication of CD is the development of …

Background and aim Forkhead box protein O4 (FOXO4) is a transcription factor, and
aberrant FOXO4 expression is associated with development of various human cancers. This …

Recent progress in epigenetic research has made a profound influence on
pharmacoepigenomics, one of the fastest growing disciplines promising to provide new epi …