Erlotinib complexation with randomly methylated β-cyclodextrin improves drug solubility, intestinal permeability, and therapeutic efficacy in non-small cell lung cancer
… The purpose of this study was to investigate the impact of anticancer drug erlotinib-randomly …
Phase solubility study showed erlotinib displayed maximum solubility in RAMEB CD …
Phase solubility study showed erlotinib displayed maximum solubility in RAMEB CD …
[HTML][HTML] Assessment of erlotinib pharmacodynamics in tumors and skin of patients with head and neck cancer
… of the study was to evaluate the effects of erlotinib on epidermal … Steady-state trough
concentrations of erlotinib and its … C ss,min values for erlotinib and OSI-420 also related to TTP (P …
concentrations of erlotinib and its … C ss,min values for erlotinib and OSI-420 also related to TTP (P …
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
… and erlotinib. To identify other potential mechanisms that contribute to disease progression,
we used array-based comparative … Growth inhibition studies demonstrate that these cells are …
we used array-based comparative … Growth inhibition studies demonstrate that these cells are …
Structure guided design and binding analysis of EGFR inhibiting analogues of erlotinib and AEE788 using ensemble docking, molecular dynamics and MM-GBSA
VK Sharma, PP Nandekar, A Sangamwar… - RSC …, 2016 - pubs.rsc.org
… and AQ4_AN (erlotinib analogue) could act as potential EGFR inhibitors. The study thus
provides an … It is expected that this study will be beneficial for design and discovery of new lead …
provides an … It is expected that this study will be beneficial for design and discovery of new lead …
Pharmacokinetic properties of two erlotinib 150 mg formulations with a genetic effect evaluation in healthy Korean subjects
HG Choi, JY Jeon, YJ Im, Y Kim, EK Song… - Clinical drug …, 2015 - Springer
… and the pharmacokinetics of erlotinib were not observed, except CYP1A2*1M in this study, …
of plasma concentration of erlotinib is in the regular range who are treated erlotinib in Asian, …
of plasma concentration of erlotinib is in the regular range who are treated erlotinib in Asian, …
Economic analysis: randomized placebo-controlled clinical trial of erlotinib in advanced non–small cell lung cancer
… study, to determine the impact of introducing erlotinib therapy on US health-care expenditure,
it was estimated ( 24 ) that erlotinib … This study estimated the cost of erlotinib therapy in the …
it was estimated ( 24 ) that erlotinib … This study estimated the cost of erlotinib therapy in the …
Design, optimization and in vitro evaluation of reverse micelle-loaded lipid nanocarriers containing erlotinib hydrochloride
S Vrignaud, J Hureaux, S Wack, JP Benoit… - International journal of …, 2012 - Elsevier
… Erlotinib hydrochloride (ERLO) belongs to the tyrosine kinase inhibitor family … study, ERLO
was entrapped in lipid nanocarriers by means of reverse micellar incorporation. This study …
was entrapped in lipid nanocarriers by means of reverse micellar incorporation. This study …
[HTML][HTML] Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: comparative pharmacokinetics and drug–drug …
S Peters, S Zimmermann, AA Adjei - Cancer treatment reviews, 2014 - Elsevier
… Erlotinib and gefitinib are especially effective in tumours with activating EGFR mutations,
evident in 10–15% of Caucasians and 40% of Asians with NSCLC [5]. In 90% of cases, these …
evident in 10–15% of Caucasians and 40% of Asians with NSCLC [5]. In 90% of cases, these …
… for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc (II) phthalocyanine and small molecule target-based anticancer drug erlotinib
FL Zhang, Q Huang, K Zheng, J Li, JY Liu… - Chemical …, 2013 - pubs.rsc.org
… In this study, two phthalocyanine–erlotinib conjugates linked by an oligoethylene glycol
chain have been synthesised and fully characterised. Having erlotinib as the targeting moiety, …
chain have been synthesised and fully characterised. Having erlotinib as the targeting moiety, …
Potential of erlotinib cyclodextrin nanosponge complex to enhance solubility, dissolution rate, in vitro cytotoxicity and oral bioavailability
… The present study was envisaged to evaluate the effect of erlotinib β-cyclodextrin … cytotoxicity
and oral bioavailability of erlotinib (ERL). Preliminary studies were conducted to select the …
and oral bioavailability of erlotinib (ERL). Preliminary studies were conducted to select the …