Harnessing programmed cell death as a therapeutic strategy in rheumatic diseases

M Ramaswamy, M Deng, RM Siegel - Nature Reviews Rheumatology, 2011 - nature.com
… (NF-κB) and mitogen-activated protein kinase (MAPK) signaling. Not … , receptors in the
AXL/TYRO3/MER family that indirectly … in a mouse collagen-induced arthritis model. These studies …

[HTML][HTML] Paeoniflorin inhibits ASK1-TF axis by up-regulating SOCS3 to alleviate radiation enteritis

L Sheng, F Hu, H Yu, X Tao, R Jia, Y Gu… - Frontiers in …, 2022 - frontiersin.org
… and limited options for therapy. Intestinal inflammation … (TYRO3, Axl, and Mer) belong to
the receptor tyrosine kinase family. In the inflammatory self-regulation cycle, the activation of Axl

Macrophage Targeting by Nanocarriers for Therapy of Autoimmune Diseases

L Biswas, M Yadav, P Singh, S Talegaonkar… - … and Therapeutic …, 2022 - Springer
… to improve therapeutic efficacy of enclosed drug. Thus, they are ideal therapeutic targets for
… -SLNs/PD nano-conjugates in collagen-induced arthritis (CIA) mice shows accumulation in …

[PDF][PDF] GR actions in stromal cells suppress inflammatory arthritis by induction of anti-inflammatory macrophages

M Koenen - 2019 - oparu.uni-ulm.de
… Ca2+/calmodulin-dependent protein kinase 2 CD … for rheumatoid arthritis is the
collagen-induced arthritis (CIA). CIA … the TAM receptors (MerTK, Axl and Tyro3), CD36 and …

Applications of oxetanes in drug discovery and medicinal chemistry

G Huang, D Hucek, T Cierpicki, J Grembecka - European Journal of …, 2023 - Elsevier
… Receptor tyrosine kinase AXL, a member of the TAM (TYRO3, AXL, MER) family, regulates
multiple … Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase from the Tec family, is …

Biological roles of liver X receptors in immune cells

M Pascual-García, AF Valledor - Archivum immunologiae et therapiae …, 2012 - Springer
… LXR agonists have indeed shown therapeutic effectiveness … for most of the lipogenic effects
of LXR agonists in this organ, … of the Axl/Mer/Tyro3 receptor tyrosine kinase family that also …

NME digest

D Navarro, R Castaner… - Drugs of the Future, 2015 - access.portico.org
… SEO-16 displayed full agonist efficacy in vitro and … TAM family of receptor tyrosine
kinases with IC50 values of 0.4… In mice with collageninduced arthritis and in those with anti-…

[HTML][HTML] Modulation of immune cell functions by the E3 ligase Cbl-b

C Lutz-Nicoladoni, D Wolf, S Sopper - Frontiers in oncology, 2015 - frontiersin.org
… receptors like receptor tyrosine kinases, G-protein-coupled … , increased collagen-induced
autoimmune arthritis induced … on cytokine production after stimulation with TLR3 agonists (…

[HTML][HTML] Inhibition of Rheumatoid Arthritis Using Bark, Leaf, and Male Flower Extracts of Eucommia ulmoides

YY Xing, JY Wang, K Wang, Y Zhang, K Liu… - Evidence-Based …, 2020 - hindawi.com
… ulmoides has potential applications as a therapeutic agent … ankle joint destruction of
collagen-induced arthritis (CIA) rats and … efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in …

[HTML][HTML] Human Synovial Mesenchymal Stem Cells Expressed Immunoregulatory Factors IDO and TSG6 in a Context of Arthritis Mediated by Alphaviruses

M Payet, A Septembre-Malaterre, P Gasque… - International Journal of …, 2023 - mdpi.com
… GAS6 and PROS1 are ligands of TAM (Tyro3, Axl and Mer) … Furthermore, injection of GAS6
and PROS1 in collagen-induced arthritis … In collagen-induced arthritis in mice, treatment with …