Averting inflammation by targeting the cytokine environment

M Kopf, MF Bachmann, BJ Marsland - Nature Reviews Drug Discovery, 2010 - nature.com
… of cytokine networks may lead to the development of highly specific therapeutics targeting
… Rather than blocking early pleiotropic cytokines, future success may lie in the combined …

Synergy and specificity in induction of gene activity by proinflammatory cytokines: potential therapeutic targets

J Spink, J Cohen - Shock, 1997 - journals.lww.com
… The proinflammatory cytokine cascade is involved in both the normal immune … novel
therapeutic drugs for the selective manipulation of these disease processes. Such potential targets

T helper type-2 cytokine responses: potential therapeutic targets

AG Jarnicki, PG Fallon - Current Opinion in Pharmacology, 2003 - Elsevier
… diseases, various therapeutic strategies that … novel therapeutic targets. In this review, we
examine recent developments in the manipulation of Th2 responses that might have therapeutic

[HTML][HTML] Cytokines: can cancer get the message?

RM Morris, TO Mortimer, KL O'Neill - Cancers, 2022 - mdpi.com
… cancer-related processes, cytokines have also become attractive therapeutic targets for cancer
… several cytokines and crucial cancer-promoting processes and their therapeutic potential. …

[HTML][HTML] Leukemia stem cells and microenvironment: biology and therapeutic targeting

MY Konopleva, CT Jordan - Journal of clinical oncology, 2011 - ncbi.nlm.nih.gov
Therapeutic targeting leukemic stem cell (LSC) niche interactions. Cytokines, chemokines,
and the … The therapeutic strategies designed to target the LSC within their surrounding …

The cytokine network in heart failure: pathogenetic importance and potential therapeutic targets.

L Gullestad, P Aukrust - Heart Failure Monitor, 2001 - europepmc.org
… influence on the cytokine network in CHF patients, and immunomodulatory therapy, in addition
to '… Thus, several small studies with therapy targeted against inflammatory mediators have …

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40

K Sugamura, N Ishii, AD Weinberg - Nature Reviews Immunology, 2004 - nature.com
… More recently, second-generation immunotherapies targeting cytokines or their receptors
that are responsible for disease pathogenesis have been established, but the consequences …

Role of inflammatory cytokines in the pathogenesis of rheumatoid arthritis and novel therapeutic targets

S Shehu, AU Kurya, DC Sharma - Asian Journal of …, 2020 - editor.journal7sub.com
… the recruitment of pro-inflammatory cytokines, specifically TNF-α… Novel therapeutic targets
are developed to minimize the … globally with more precise therapeutic effect on inflammation. …

Therapeutics targeting the innate immune system

RJ Ulevitch - Nature Reviews Immunology, 2004 - nature.com
… In this review, I discuss interesting drug targets that have emerged from recent studies of
TLRs and/or NOD proteins, without considering as targets the numerous downstream cytokines

[HTML][HTML] Biologics for targeting inflammatory cytokines, clinical uses, and limitations

P Rider, Y Carmi, I Cohen - International journal of cell biology, 2016 - hindawi.com
… of cytokines as therapeutic targets are as follows: (i) unlike in chemical drugs, specific protein
which mediate the inflammatory process can be inhibited; (ii) cytokines … these cytokines are …