Cyclic nucleotide phosphodiesterase of retinal photoreceptors: partial purification and some properties of the enzyme
JF Coquil, N Virmaux, P Mandel, C Goridis - Biochimica et Biophysica Acta …, 1975 - Elsevier
1. A cyclic nucleotide phosphodiesterase (EC 3.1. 4.16) has been partially purified from
bovine rod outer segments. The enzyme preparation obtained has a very high specific …
bovine rod outer segments. The enzyme preparation obtained has a very high specific …
Localization and function of cyclic guanosine monophosphate-phosphodiesterase activity in the retinal rods of the rat by means of a newly developed cytochemical …
S Ueno, HJ Bambauer, H Umar, M Ueck - Cell and tissue research, 1984 - Springer
Cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDEase) activity was studied
histo-and cytochemically in the retinal rods of the rat with the use of a newly developed …
histo-and cytochemically in the retinal rods of the rat with the use of a newly developed …
Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods.
WA GoRCZYCA, MP Gray-Keller… - Proceedings of the …, 1994 - National Acad Sciences
In retinal rods light triggers a cascade of enzymatic reactions that increases cGMP hydrolysis
and generates an electrical signal by causing closure of cGMP-gated ion channels in the …
and generates an electrical signal by causing closure of cGMP-gated ion channels in the …
γ‐Subunit of mouse retinal cyclic‐GMP phosphodiesterase: cDNA and corresponding amino acid sequence
N Tuteja, DB Farber - FEBS letters, 1988 - Wiley Online Library
The cDNA nucleotide and corresponding amino acid sequences of the γ‐subunit of cyclic‐
GMP phosphodiesterase (cGMP‐PDEγ) from mouse retina have been determined. The …
GMP phosphodiesterase (cGMP‐PDEγ) from mouse retina have been determined. The …
Photoreceptor degeneration in a pure-cone retina. Effects of cyclic nucleotides, and inhibitors of phosphodiesterase and protein synthesis.
DS Williams, NJ Colley… - … ophthalmology & visual …, 1987 - iovs.arvojournals.org
Previous studies have shown that disruption of cyclic nucleotide metabolism by
phosphodiesterase inhibitors and cyclic nucleotide analogues damages photoreceptors in …
phosphodiesterase inhibitors and cyclic nucleotide analogues damages photoreceptors in …
Detection of cGMP in the degenerating retina
S Michalakis, J Xu, M Biel, XQ Ding - Guanylate Cyclase and Cyclic GMP …, 2013 - Springer
Abstract Cyclic guanosine 3′-5′-monophosphate (cGMP) plays a key role in the
physiological process of light detection in photoreceptor cells of the retina. However, there is …
physiological process of light detection in photoreceptor cells of the retina. However, there is …
[引用][C] Cyclic GMP-regulated cyclic nucleotide phosphodiesterases
DJ Takemoto, K Gonzalez, I Udovichenko, J Cunnick - Cellular signalling, 1993 - Elsevier
CYCLIC nucleotide phosphodiesterases comprise a family of related proteins which can be
divided into five major PDE families [1, 2]. These are:(i) a Ca+-calmodulin-sensitive PDE …
divided into five major PDE families [1, 2]. These are:(i) a Ca+-calmodulin-sensitive PDE …
Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.
Retinal rod outer segments contain a phosphodiesterase specific for cyclic GMP. This
enzyme is virtually inactive in the dark. Photoexcitation of rhodopsin results in the formation …
enzyme is virtually inactive in the dark. Photoexcitation of rhodopsin results in the formation …
Cyclic GMP phosphodiesterase from bovine retina. Amino acid sequence of the alpha-subunit and nucleotide sequence of the corresponding cDNA.
O YuA, VV Gubanov, NV Khramtsov, KA Ischenko… - FEBS letters, 1987 - europepmc.org
The alpha-subunit primary structure of cyclic GMP phosphodiesterase has been determined
by parallel analysis of the protein amino acid sequence and the corresponding cDNA …
by parallel analysis of the protein amino acid sequence and the corresponding cDNA …
Guanosine 3', 5'-cyclic nucleotide binding proteins of bovine retina identified by photoaffinity labeling.
DA Thompson, HG Khorana - Proceedings of the National …, 1990 - National Acad Sciences
Cyclic GMP-binding proteins present in membrane fractions of bovine retina and, in
particular, rod outer segments (ROS) were identified by photoaffinity labeling with 8-azido …
particular, rod outer segments (ROS) were identified by photoaffinity labeling with 8-azido …