Well over a decade ago a central role of tumor necrosis factor (TNF) was first described in
patients with rheumatoid arthritis (RA) when remarkable clinical benefit was demonstrated in …

The Notch and NF-κB signaling pathways regulate stem cell function and inflammation in the
gut, respectively. We investigate whether a functional cross talk exists between the two …

Abstract Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key
regulator of mucosal homeostasis within the gastrointestinal tract. Like other members of this …

Chronic obstructive pulmonary disease (COPD) is a treatable and preventable disease
state, characterised by progressive airflow limitation that is not fully reversible. Although …

Background Chemokines regulate the pathways that restrict homing of specific subsets of
immune cells, and thereby fine tune the immune response at specific lymphoid and …

Abstract IL-23 属于IL-12 家族, 他可由IL-12 P40 亚单位和IL-23 P19 亚单位通过二硫键形成的
异二聚体分子, 通过结合T 细胞表面上的受体复合物(IL-12Rb1 和IL-23R 构成) 激活Stat1, Stat3 …

Methods CD patients who started UST were prospectively enrolled from 4 hospitals in
Korea. All enrolled patients received intravenous UST infusion at week 0 and subcutaneous …

Thalidomide is an oral immunomodulatory and anti-inflammatory drug with antitumor
necrosis factor-α (TNF-α) activity. Several case reports and some clinical trials have …

Abstract Golgi phosphoprotein 2 (GOLPH2) is a very important biomarker in a variety of
diseases. Its biological function is not clear, particularly in gastric cancer. To investigate the …

Background: The protective effect of the chloroform extract of Cyperus rotundus (CHCR) is
attributed to its anti-inflammatory and antioxidant activities. Cytokines, important regulators …