Antigen-Presenting Cells and the Major Histocompatibility Complex

C Carlberg, E Velleuer - Molecular Immunology: How Science Works, 2022 - Springer
In this chapter, we will discuss the principles of antigen presentation. We will learn that the
major purpose of antigen-presenting cells, such as dendritic cells, macrophages and B cells, …

A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants

ES Rice, A Alberdi, J Alfieri, G Athrey, JR Balacco… - BMC biology, 2023 - Springer
… variants present in modern breeds and untangle complex nested variation. We show that …
of a large and complex pair of structural variants at the K feathering locus using short reads, …

Long-read assembly of major histocompatibility complex and killer cell immunoglobulin-like receptor genome regions in cynomolgus macaque

Q Hu, X Huang, Y Jin, R Zhang, A Zhao, Y Wang… - Biology Direct, 2022 - Springer
… The major histocompatibility complex (MHC) and the killer cell immunoglobulin-like
receptors (KIR) … We identified functional Mafa-B loci at the transcriptome level using locus-specific …

The Host Response to Grafts and Transplantation Immunology

AH Johnson - Infection, Resistance, and Immunity, Second …, 2022 - taylorfrancis.com
… a similar set of molecules called H-2 or Histocompatibility-Locus 2 antigens. All vertebrates
studied to date possess a major histocompatibility complex. ln the mouse, the MHC is found …

Polygenic risk score prediction of multiple sclerosis in individuals of South Asian ancestry

JR Breedon, CR Marshall, G Giovannoni… - Brain …, 2023 - academic.oup.com
… the major histocompatibility complex region, the most influential locus in determining … the
major histocompatibility complex) and 1.5% (excluding the major histocompatibility complex) of …

Genetic diversity of the major histocompatibility complex by using LEI0258 microsatellite marker associated with productive performance and viral diseases in broiler …

FS Nassar - Egyptian Poultry Science Journal, 2021 - epsj.journals.ekb.eg
The chicken Major Histocompatibility Complex (MHC) is closely related to resistance to
several diseases. Moreover, selection for genetic resistance to diseases is a critical goal in the …

Major histocompatibility complex class I assembly within endolysosomal pathways

E Olson, M Raghavan - Current Opinion in Immunology, 2023 - Elsevier
complex (PLC), including tapasin, calreticulin, and ERp57 1, 3. The PLC stabilizes the MHC
class I dimer and brings the complex … Structures of TAPBPR in complex with MHC class I …

[HTML][HTML] Deciphering the complexity of 3D chromatin organization driving lymphopoiesis and lymphoid malignancies

L Scourzic, E Salataj, E Apostolou - Frontiers in Immunology, 2021 - frontiersin.org
… In murine CD8 + cells, the expression of Cd8 locus is … complex in DP cells or ThPOK in
CD8 + cells (82). These chromatin contacts are significantly lower in B cells, where Cd8 locus is …

Innate immune genes of the chicken MHC and related regions

J Kaufman - Immunogenetics, 2022 - Springer
… The chicken MHC is embedded in a larger historical genetic region called the B locus (or
sometimes, the B complex), which was originally described based on the reactivity of …

Combining genotypes and T cell receptor distributions to infer genetic loci determining V (D) J recombination probabilities

ML Russell, A Souquette, DM Levine, SA Schattgen… - Elife, 2022 - elifesciences.org
locus, we also identified 1242 significant SNP associations within the major histocompatibility
complex (MHC) locus… with variation in the MHC locus. For the significantly associated MHC …