The Interferon-Alpha Revival in CML

M Talpaz, J Mercer, R Hehlmann - Chronic Myeloid Leukemia, 2021 - Springer
… wild-type cells in competitive repopulation assays [36]. … in monitoring or even predicting
response to IFNα therapy. … improve adherence to treatment without reducing efficacy, and …

Management of chronic myeloid leukaemia

JM Goldman - Blood reviews, 1994 - Elsevier
Interferon alpha overrides the deficient adhesion of CML … by polymerase chain reaction in
Philadelphia chromosome-positive chronic myelogenous leukemia following interferon therapy

Molecular basis for therapeutic decisions in chronic myeloid leukemia patients after allogeneic bone marrow transplantation

J Roman, MA Alvarez, A Torres - Haematologica, 2000 - haematologica.org
… methods to the monitoring of treatment efficacy and early … Should polymerase chain reaction
analysis to detect minimal residual disease in patients with chronic myelogenous leukemia

Chronic myelogenous leukemia: disease biology and current and future therapeutic strategies

H Kantarjian, JV Melo, S Tura, S Giralt… - ASH Education …, 2000 - ashpublications.org
… ): 1) allogeneic stem cell transplant (SCT); 2) interferon alpha (… of chemical structures capable
of competing with the ATP or … efficacy and allow successful strategies in CML outside the …

Diagnosis and monitoring of chronic myeloid leukemia by qualitative and quantitative RT-PCR

S Branford, T Hughes - Myeloid Leukemia: Methods and Protocols, 2006 - Springer
… are usually detectable by the polymerase chain reaction (PCR) … The assay performance is
monitored by quality control samples … pretreated with interferon alpha. Low levels of residual …

Chronic myeloid leukemia: 2016 update on diagnosis, therapy, and monitoring

E Jabbour, H Kantarjian - American journal of hematology, 2016 - Wiley Online Library
… Baseline reverse transcriptase-polymerase chain reaction is … It acts via competitive inhibition
at the ATP-binding site of the … with other available (peg-interferon alpha-2, omacetaxine, …

Persistence of transcriptionally silent BCR-ABL rearrangements in chronic myeloid leukemia patients in sustained complete cytogenetic remission

A Kitzis, F Brizard, C Dascalescu, JC Chomel… - Leukemia & …, 2001 - Taylor & Francis
… knowledge on monitoring of MRD in CML patients who obtained CCR after … chronic
myelogenous leukemia patients on Interferon-alpha therapy by competitve polymerase chain reaction

New insights in biology and current therapeutic options for patients with chronic myelogenous leukemia

AM Carella, F Frassoni, J Melo, C Sawyers… - …, 1997 - haematologica.org
… demonstrated that interferon alpha therapy is indicated and … , or reverse transcription/polymerase
chain reaction (RT/PCR) ampli… , the best way to monitor individual patients and the best …

Comparison of the cytogenetic and molecular analyses in the assessment of imatinib response in chronic myelocytic leukemia

S Palanduz, A Bayrak, S Sirma, B Vural… - Genetic Testing and …, 2009 - liebertpub.com
… real-time reverse transcriptase polymerase chain reaction (QR-PCR) and … Monitoring
IM-treated CML patients with cytogenetic and … treated with imatinib after failure of interferon alpha. …

[HTML][HTML] Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs: A literature review

MM Sampaio, MLC Santos, HS Marques… - World journal of …, 2021 - ncbi.nlm.nih.gov
… , prognosis, treatment, and monitoring of CML. The discovery … through reverse transcriptase
polymerase chain reaction (RT-… and has fewer adverse effects than interferon-alpha (IFN-a)[…