Aging, which affects all organ systems, is one of the most complex phenotypes. Recent
discoveries in long-lived mutant mice have revealed molecular mechanisms of longevity in …

Mutant mice with a combined deficiency of growth hormone (GH), prolactin, and thyrotropin,
and knockout mice with GH resistance, live longer than their normal siblings. The extension …

Mice are excellent experimental models for genetic research and are being used to
investigate the genetic component of organismal aging. Several mutant mice are known to …

We recently found that lithocholic acid (LCA), a bile acid, extends yeast longevity. Unlike
mammals, yeast do not synthesize bile acids. We therefore propose that bile acids released …

A positive relationship between stress resistance and longevity has been reported in a
multitude of studies in organisms ranging from yeast to mice. Several mouse lines have …

Growth hormone receptor gene–disrupted (GHR−/−) mice are dwarf, insulin sensitive, and
long lived despite being obese. In order to identify characteristics associated with their …

The delay of aging and healthy life extension is a primary concern of modern gerontological
research. Based on theoretical assumptions and empirical findings, a number of bioactive …

We all—more or less—think about aging, and our ancestors did too. In Greek mythology, the
god of old age, Geras, was often depicted as a shriveled-up old man holding a cane, while …

Growth hormone (GH) affects somatic growth, sexual maturation, body composition and
metabolism, as well as aging and longevity. Mice lacking GH or GH receptor outlive their …

Primary bile acids are synthesized from cholesterol in the liver and thereafter are secreted
into the bile and small intestine. Gut flora modify primary bile acids to produce secondary …