Thyroxine (T4) is a prohormone and must be activated to 3, 5, 3′-triiodothyronine (T3) by
either type 1 (D1) or type 2 (D2) selenodeiodinase. A third deiodinase (D3) inactivates T3 or …

The testis has been classically described as a thyroid hormone unresponsive tissue, but
recent studies indicate that these hormones might play an important role in developing …

Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity,
which both preserves the circulating levels of the biologically active triiodothyronine (T3) and …

Radioiodide was injected into newborn rats, their thyroids were digested and the digests
fractionated by paper chromatography. Rats born to iodine—deficient dams were studied at …

Abstract Thyroxine 5′-deiodinase (5′ D) catalyses deiodination of the prohormone
thyroxine (T 4) to the metabolically active hormone 3, 5, 3′-tri-iodothyronine (T 3) …

Type I 5′-deiodinase (5′ DI) is crucial for the generation of circulating 3, 5, 3′-
triiodothyronine (T3) and so is a major determinant of thyroid hormone action. Liver and …

The thyroid hormones (TH) are essential for normal development in vertebrate species. This
review considers the roles that the three deiodinases, types 1, 2 and 3 (D1, D2, and D3) …

Type 1 and 2 iodothyronine deiodinases (D1 and D2) catalyze thyroxine (T4) activation. In
human thyroid, unlike rodents', both D1 and D2 are expressed. We have investigated the …

Background: Iodine is essential for thyroid hormone synthesis and is an important regulator
of thyroid function. Chronic iodine deficiency leads to hypothyroidism, but iodine excess also …

The aim of this study was to characterize the type of 50-deiodinase activity in the prostate of
pubescent rats (7–8 weeks), to establish its distribution in the lobes (ventral, dorsolateral …