The ongoing threat of viral infections and the emergence of antiviral drug resistance
warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds …

HIV‐1 Vpu catalyzes two independent functions, degradation of the virus receptor CD4 in
the endoplasmic reticulum and enhancement of virus release from the cell surface. These …

Influenza is a persistent threat to human health and there is a continuing requirement for
updating anti-influenza strategies. Initiated by observations of different endoplasmic …

In this review, we will discuss drug design based on proven and potential anti-influenza drug
targets including viral hemagglutinin (HA), neuraminidase (NA), M2 ion channel, 3P …

The influenza B virus BM2 proton-selective ion channel is essential for virus uncoating, a
process that occurs in the acidic environment of the endosome. The BM2 channel causes …

Background Viroporins are virally encoded ion channels involved in virus assembly and
release. Human immunodeficiency virus type 1 (HIV-1) and influenza A virus encode for …

Eukaryotic cells have evolved a myriad of ion channels, transporters, and pumps to maintain
and regulate transmembrane ion gradients. As intracellular parasites, viruses also have …

Viral ion channels or viroporins are short membrane proteins that participate in wide-ranging
functions including virus replication and entry, assembly, and virus release. One such …

Vpu, an integral membrane protein encoded in HIV-1, is implicated in the release of new
virus particles from infected cells, presumably mediated by ion channel activity of homo …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …