The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of
plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an …

It has long been recognized that the secretion of PTH by chief cells in the parathyroid gland
is regulated by extracellular ionized calcium. The molecular mechanism by which …

Abstract Ca 2+-sensing receptors (CaSR) are G protein-coupled receptors which are
activated by a rise in extracellular Ca 2+. CaSR activation has been known to inhibit …

Calcimimetic compounds inhibit not only parathyroid hormone (PTH) synthesis and
secretion, but also parathyroid cell proliferation. The aim of this investigation is to examine …

A hallmark of chronic kidney disease is hyperphosphatemia due to renal phosphate
retention. Prolonged parathyroid gland exposure to hyperphosphatemia leads to secondary …

The extracellular calcium receptor (CaR) is a G protein-coupled receptor (GPCR) and the
pivotal molecule regulating systemic Ca 2+ homeostasis. The CaR was a challenging target …

The calcium sensing receptor (CaSR) was first identified in parathyroid glands, and its
primary role in controlling systemic calcium homeostasis by the regulation of parathyroid …

In addition to its acute effects on hormone secretion, epithelial transport, and shape change,
the calcium-sensing receptor (CaSR) modulates the expression of genes that control cell …

The intracellular movement of calcium, through calcium channels, plays a major role on
sperm cell function. The calcium‐sensing receptor (CaSR), a molecular mechanism by …

Parathyroid hormone–related protein (PTHrP) contributes to the development and metastatic
progression of breast cancer by promoting hypercalcemia, tumor growth, and osteolytic …