Immunostimulating complexes (ISCOMs) are known to be highly effective adjuvants for
envelope antigens of viral agents, but have not been evaluated for use with antigens of …

ABSTRACT A safer and more effective vaccine than the previously developed live
attenuated vaccine is needed for combating Francisella tularensis, a highly infectious …

A colony (N83) of the vaccine strain of Francisella tularensis (15/10) and a strain (N268)
isolated from a water sample in nature were revealed for susceptibility to cultivation at 42° C …

Pneumonic tularemia is a life-threatening disease caused by inhalation of the highly
infectious intracellular bacterium Francisella tularensis. The most serious form of the disease …

The host response to experimental murine tularemia was examined in different inbred
mouse strains. The kinetics of growth of Francisella tularensis live vaccine strain (LVS) in the …

Francisella tularensis can cause severe disseminated disease after respiratory infection.
The identification of factors involved in mortality or recovery following induction of tularemia …

Both serum and spleen cells from mice immune to Francisella tularensis transfer protection
to naive recipients. Here we characterize the mechanism of protection induced by transfer of …

Francisella tularensis, a gram-negative, facultative, intracellular bacterium, is the etiologic
agent of tularemia and a category A bioterrorism agent. Little is known about the mechanism …

Cytokine mRNA expression was determined in the liver of mice subcutaneously inoculated
with a lethal dose of the highly virulent strain FSC 041 of Francisella tularensis subvar …

Francisella tularensis, the causative agent of tularemia and Category A biodefense agent, is
known to replicate within host macrophages, though the pathogenesis of this organism is …