The physiological importance of 5α-reductase (5α-R)(EC 1· 3· 99· 5) in the brain may derive
from two of its properties: its capability to convert testosterone (T) to a more potent androgen …

The aim of the present report was to study the role of high levels of dehydroepiandrosterone
(DHEA) on the ovarian function and embryonic resorption during early pregnancy in BALB/c …

Dihydrotestosterone (DHT) is the most potent naturally occurring androgen, and its
production in the testis may have important consequences in developmental and …

In mammals, hormonal regulation during gestation is crucial for embryo implantation and
pregnancy success. This regulation is controlled through the level of progesterone (P4) that …

Testosterone's (T) aggression-enhancing effects may be mediated in part by its 5α-reduced,
3-hydroxysteroid dehydrogenized metabolite 5α-androstane-3α, 17β-diol (3α-diol). To test …

Abstract Hydroxysteroid (17-β) dehydrogenase 2 (HSD17B2) is a member of aldo-keto
reductase superfamily, known to catalyze the inactivation of 17β-hydroxysteroids to less …

Plasma concentrations of N-arachidonyletholamine (AEA), N-oleoylethanolamide (OEA) and
N-palmitoylethanolamide (PEA) increase at term and can predict when a woman is likely to …

Objective Testosterone has been postulated to be involved in ALS causation. Materials and
methods CSF levels of free testosterone and dihydrotestosterone were measured in 13 ALS …

Abstract 5α-Reductases irreversibly catalyse A-ring reduction of pregnene steroids,
including glucocorticoids and androgens. Genetic disruption of 5α-reductase 1 in male mice …

Elevated levels of LH have been associated with infertility and miscarriage in women.
Previously, we have reported generating a transgenic mouse model that hypersecretes LH …