Developing oncolytic viruses for the treatment of cervical cancer

E Kalafati, E Drakopoulou, NP Anagnou, KI Pappa - Cells, 2023 - mdpi.com
… efficacy of AdVs harboring the cyclooxygenase-2 (Cox-2) or the … in a phase I/II study in head
and neck cancer patients, combined … within the tumor microenvironment, facilitating immune …

Phosphatidylinositol 3-kinase signaling as a therapeutic target for cervical cancer

J Wu, C Chen, KN Zhao - Current cancer drug targets, 2013 - ingentaconnect.com
… In addition to cyclooxygenase-2 (COX-2) and serum … p-AKT is a biomarker for poor prognosis
in cervical cancer. Radiation … Thus, It was recommended that additional phase I/II trials are …

Immune alterations and immunotherapy prospects in head and neck cancer

V Varilla, J Atienza, CA Dasanu - Expert opinion on biological …, 2013 - Taylor & Francis
… The importance of tumor microenvironment in HNSCC will … Furthermore, cyclooxygenase
2 (COX-2) overexpression and … There is currently a Phase I/II study that seeks to evaluate …

Leveraging innovative therapies with an evolving understanding of the molecular pathogenesis of penile squamous cell carcinoma

A Hajiran, T Bracco, L Zemp, PE Spiess - Urologic Oncology: Seminars and …, 2022 - Elsevier
Cyclooxygenase-2 inhibition in combination with … interesting ongoing phase I/II clinical trial
that is a assessing the use of … cancer tumor microenvironment is highly complex, with various …

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

P Gascard, TD Tlsty - Genes & development, 2016 - genesdev.cshlp.org
… Example of a p53/activin A/cyclooxygenase-2 (COX-2)-… greatly on tumor microenvironment
and cancer type (ie, FAP … been terminated despite promising phase I/II results. A pilot …

How to overcome tumor resistance to anti-PD-1/PD-L1 therapy by immunotherapy modifying the tumor microenvironment in MSS CRC

L Chen, X Jiang, Y Li, Q Zhang, Q Li, X Zhang… - Clinical …, 2022 - Elsevier
… within tumor cells is a reliable biomarker for … phase I/II clinical trial has been arranged to
investigate the effects of combining NOX-A12 and anti-PD-1/PD-L1 treatment in CRC patients

Progress in targeted therapeutic drugs for oral squamous cell carcinoma

L Liu, J Chen, X Cai, Z Yao, J Huang - Surgical oncology, 2019 - Elsevier
biomarkers and the limited sample size, mTOR inhibitor … and ribociclib are being tested
in phase I/II clinical trials. … It has been found that celecoxib could significantly inhibit the …

Angiogenesis and anti-angiogenic treatment in prostate cancer: mechanisms of action and molecular targets

E Ioannidou, M Moschetta, S Shah, JS Parker… - International journal of …, 2021 - mdpi.com
… The clinical utility of molecular and image-based biomarkers … β (TGFβ) and cyclooxygenase-2
(COX-2) [30,31,32,33]. The … in the formation of the tumor microenvironment mainly via their …

The route to personalized medicine in bladder cancer: where do we stand?

F Massari, C Ciccarese, M Santoni, M Brunelli… - Targeted …, 2015 - Springer
… A phase I/II trial of everolimus and intravesical gemcitabine in … COX-2 inhibitor celecoxib in
preventing recurrence of … in the tumor microenvironment, such as cancers have learned how …

Prospects of molecularly-targeted therapies for cervical cancer treatment

A Carlos de Freitas… - Current drug …, 2015 - ingentaconnect.com
prospective phase I-II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with
carcinoma of the cervix with biomarker assessment of the tumor microenvironment. Int J Radiat …