Semaglutide for obesity: four STEPs forward, but more to come

DH Ryan - The Lancet Diabetes & Endocrinology, 2021 - thelancet.com
Semaglutide 2·4 mg once weekly, an anti-obesity medication now submitted to regulators
across … Semaglutide effects on cardiovascular outcomes in people with overweight or obesity (…

[PDF][PDF] Semaglutide: The first anti-obesity agent shown to decrease cardiovascular events

MD Nasser Mikhailand, S Wali - diabeticjournals.net
semaglutide as the first anti-obesity drug shown to decrease CV events in subjects with
obesity and prevalent CV … The mechanisms whereby semaglutide decreased CV outcomes are …

Once‐weekly semaglutide reduces the risk of cardiovascular events in people with type 2 diabetes and polyvascular disease: A post hoc analysis

O Kobo, MA Cavender, TJ Jensen… - Diabetes, Obesity …, 2024 - Wiley Online Library
… OW semaglutide compared with placebo was associated with a consistent reduction in CV
outcomes … those without vascular disease, and a 3.5 times greater risk of expanded composite …

Effect of the glucagon-like peptide-1 receptor agonists semaglutide and liraglutide on kidney outcomes in patients with type 2 diabetes: pooled analysis of SUSTAIN 6 …

AM Shaman, SC Bain, GL Bakris, JB Buse, T Idorn… - Circulation, 2022 - Am Heart Assoc
… Secondary kidney outcomes in these cardiovascular outcome … of semaglutide in SUSTAIN
6 and liraglutide in LEADER, compared with placebo, on clinically important kidney outcomes, …

The antiobesity effect and safety of GLP-1 receptor agonist in overweight/obese patients without diabetes: a systematic review and meta-analysis

X Guo, Z Zhou, X Lyu, H Xu, H Zhu… - Hormone and …, 2022 - thieme-connect.com
semaglutide. Therefore, the aim of our study was to first evaluate the antiobesity effect of
semaglutide … , exenatide and semaglutide in the overweight/obese without diabetes in terms of …

Cardiovascular outcomes trials for weight loss interventions: another tool for cardiovascular prevention?

IJ Neeland, DK McGuire, N Sattar - Circulation, 2021 - Am Heart Assoc
… in Patients With Overweight or Obesity) with semaglutide 2.4 mg SQ … not clear whether these
trials will demonstrate improved cardiovascular outcomes, given the potential for an obesity

Effect of semaglutide on coronary atherosclerosis progression in patients with type II diabetes: rationale and design of the semaglutide treatment on coronary …

S Hamal, L Cherukuri, K Shaikh… - Coronary artery …, 2020 - journals.lww.com
… derived outcomes from liraglutide effect and action in diabetes: evaluation … cardiovascular
outcome results and semaglutide and cardiovascular outcomes in patients with type 2 diabetic

Cardiovascular outcomes trials with glucagon‐like peptide‐1 receptor agonists: a comparison of study designs, populations and results

KM Pantalone, K Munir, CM Hasenour… - Diabetes, Obesity …, 2020 - Wiley Online Library
… Like SUSTAIN-6, PIONEER 6 was designed to exclude an 80% excess in CV risk for oral
semaglutide compared with placebo, with an upper limit of the two-sided 95% CI not exceeding …

Safety and tolerability of semaglutide across the SUSTAIN and PIONEER phase IIIa clinical trial programmes

VR Aroda, U Erhan, P Jelnes, JJ Meier… - Diabetes, Obesity …, 2023 - Wiley Online Library
… Fatal AE incidence was similar between semaglutide and … adverse cardiovascular events
with subcutaneous semaglutideCardiovascular outcomes for patients at high cardiovascular

Impact of microvascular disease on cardiovascular outcomes in type 2 diabetes: results from the LEADER and SUSTAIN 6 clinical trials

S Verma, SC Bain, JB Honore… - Diabetes, Obesity …, 2020 - Wiley Online Library
… and semaglutide consistently reduced major CV outcomes in patients with and without
the impact of microvascular disease in type 2 diabetes on CV risk, and this study represents an …