[PDF][PDF] Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain

G Chen, YQ Zhang, YJ Qadri, CN Serhan, RR Ji - Neuron, 2018 - cell.com
… causes remarkable microgliosis in the spinal cord. Gliosis is a … also contributes to bone
cancer pain in female rats inoculated … Persistent upregulation of astrocytic connexin-43 (Cx43) …

[HTML][HTML] Neuropathic pain: biomolecular intervention and imaging via targeting microglia activation

A Ji, J Xu - Biomolecules, 2021 - mdpi.com
… These changes result in the up-regulation of IL-1β, NMDAR and … of NP as it inhibits
vincristine-induced hyperalgesia in rats. Its … by inhibiting the activation of rat spinal cord microglia …

[HTML][HTML] Mechanisms of chemotherapy-induced peripheral neuropathy

R Zajączkowska, M Kocot-Kępska, W Leppert… - International journal of …, 2019 - mdpi.com
… with an increased risk and severity of vincristine-induced neuropathy [201]. … leads to an
increase in the release of presynaptic glutamate at the level of the dorsal horn of the spinal cord

Neuron–microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

M Tsuda, K Inoue - Neuropharmacology, 2016 - Elsevier
… in the dorsal horn of the spinal cord. A growing body of evidence … with tactile allodynia,
indicating that P2X4R might contribute to … Extracellular ATP triggers tumor necrosis factor-alpha

HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons

X Liu, L Zhang, L Jin, Y Tan, W Li, J Tang - Molecular Pain, 2018 - journals.sagepub.com
allodynia. To examine the role of HCN2 in oxaliplatin-induced neuropathic pain, we detected
HCN2 mRNA and protein expression in the spinal cordmechanical allodynia in rats. In our …

Neuroprotective Effect of Pterocarpus Marsupium Marketed Capsules against Vincristine Induced Neuropathy in Rats

N Shaju - 2017 - repository-tnmgrmu.ac.in
spinal cord compression. Nocifensive signs crushing of … The analgesic effects of Fucoidan
contributed to an … of L-TAMS completely blocked up-regulation of TNF-α but partially blocked …

[HTML][HTML] Netazepide, an Antagonist of Cholecystokinin Type 2 Receptor, Prevents Vincristine-Induced Sensory Neuropathy in Mice

A Bernard, M Mroué, S Bourthoumieu, M Boyce… - Pharmaceuticals, 2024 - mdpi.com
vincristine-induced mechanical allodynia. Netazepide 5 mg/kg restored normal mechanical
sensitivity similar to Veh-Ctrl mice … in the spinal cord during exposure to vincristine leads to …

[HTML][HTML] Blockade of IL-6 signaling prevents paclitaxel-induced neuropathy in C57Bl/6 mice

P Huehnchen, H Muenzfeld, W Boehmerle… - Cell death & …, 2020 - nature.com
… Thoracic and lumbar spinal cords from treated mice were … -6 deficient mice develop mechanical
allodynia following PTX … This analysis supports the observation that PTX treatment leads

Upregulation of CCL2 via ATF3/c-Jun interaction mediated the Bortezomib-induced peripheral neuropathy

C Liu, S Luan, H OuYang, Z Huang, S Wu, C Ma… - Brain, behavior, and …, 2016 - Elsevier
… CCL2 upregulation and mechanical allodynia in the rats treated with … BTZ induced mechanical
allodynia and up-regulation of … might contribute to the BTZ-induced mechanical allodynia. …

Current understanding of the molecular mechanisms of chemotherapy-induced peripheral neuropathy

X Chen, Y Gan, NPB Au, CHE Ma - Frontiers in Molecular …, 2024 - frontiersin.org
… A protected the mice against vincristine-induced loss of … was detected in the cerebrospinal
fluid (CSF) of the rats. It resulted in … mice fail to induce up-regulation of dynorphin in the spinal