Abstract The epithelial Na+ channel (ENaC) contributes to the clearance of fetal lung liquid.
In premature infants, low ENaC activity and low expression level of α‐ENaC have been …

Hypoxia reduces alveolar liquid clearance and the nasal potential difference, a marker of
airway epithelial sodium transport. The mechanisms underlying this impaired epithelial …

FLUID SECRETION INTO THE DEVELOPING lungs' air spaces is essential for normal lung
development, but this fluid must be cleared at birth so that effective gas exchange can occur …

Sodium absorption by an amiloride-sensitive channel is the main driving force of lung liquid
clearance at birth and lung edema clearance in adulthood. In this study, we tested whether …

To determine whether epithelial ion transport is physiologically important for lung water
clearance after birth, the sodium transport inhibitor amiloride or its vehicle saline was given …

β-Adrenergic receptors (β-AR) increase epithelial sodium channel (ENaC) activity to
promote lung fluid clearance. However, the effect of selective β-AR agonist on highly …

Respiratory morbidity in near term (≥ 34 and< 37 weeks) infants delivered spontaneously or
by elective cesarean section (ECS) has been well documented in the literature, and …

Alveolar fluid clearance is driven by vectorial Na+ transport and promotes postnatal lung
adaptation. The effect of insulin on alveolar epithelial Na+ transport was studied in isolated …

Alveolar hypoxia may impair sodium-dependent alveolar fluid transport and induce
pulmonary edema in rat and human lung, an effect that can be prevented by the inhalation of …

Effective mucociliary clearance of secretions by airway mucosa requires efficient ciliary
beating. The structure of airway secretions provides for this requirement by having a viscous …