BcgI is a novel, multi-subunit, restriction-modification (RM) system that differs from all the
other types of RM system in its genetic and functional organization. The holoenzyme …

Spontaneous formation of isoaspartyl residues (isoAsp) disrupts the structure and function of
many normal proteins. Protein isoaspartyl methyltransferase (PIMT) reverts many isoAsp …

Isopentenyl diphosphate isomerase (IDI) activates isopentenyl diphosphate (IPP) for
polymerization by converting it to its highly nucleophilic isomer dimethylallyl diphosphate …

DNA methylation-dependent restriction enzymes have many applications in genetic
engineering and in the analysis of the epigenetic state of eukaryotic genomes. Nevertheless …

Isopentenyl diphosphate (IPP) isomerase catalyzes an essential activation step in the
isoprene biosynthetic pathway. The Saccharomyces cerevisiae gene for IPP isomerase …

The emergence of antibiotic-resistant bacterial strains is a widespread problem in medical
practice and drug design, and each case requires the elucidation of the underlying …

UDP-galactose 4-epimerase is one of three enzymes in the metabolic pathway that converts
galactose into glucose1-phosphate. Specifically this enzyme catalyzes the interconversion …

The non‐hydrolysing bacterial UDP‐N‐acetylglucosamine 2‐epimerase (UDP‐GlcNAc 2‐
epimerase) catalyses the conversion of UDP‐GlcNAc into UDP‐N‐acetylmannosamine, an …

The SPOUT family of enzymes makes up the second largest of seven structurally distinct
groups of methyltransferases and is named after two evolutionarily related RNA …

Guided by comparative sequence considerations, we have examined the possibility of a
catalytic role of Asp 186 of d-ribulose 5-phosphate epimerase by site-directed mutagenesis …