It is well established that brain structures and cognitive functions change across the life
span. A long-standing hypothesis called “age differentiation” additionally posits that the …

Background Converging evidence suggests that the pathophysiologic processes in the
brains of Alzheimer's disease (AD) patients begin decades before symptoms occur 1–3 …

Objective: Increased variability in cognition with age has been argued as an indication of
pathological processes. Focusing on early detection of neurodegenerative disorders, we …

Objective: To investigate the global and topographic changes of white matter integrity and
cortical structure related to cognitive impairments in a community-based population …

Background Considerable heterogeneity in cognitive trajectories has been well documented
in studies of older individuals from diverse samples, including minority communities. Such …

Aims: To investigate the interplay between gray matter (GM) and white matter (WM)
neurodegeneration in subjective cognitive decline (SCD), including thickness across the …

Methods: 40 (21 men, 19 women) surviving participants of the Scottish Mental Survey of
1932 were studied. Subjects IQ was tested at age 11 in June 1932 using the Moray House …

The structure and the function of the adult human brain are shaped by socioenvironmental
factors that occur across the life course. These factors may contribute towards development …

Background: Evidence suggests birth cohort differences in cognitive performance of older
adults. Proxies of cognitive reserve (CR), such as educational attainment and occupational …