1 The subtype of α1‐adrenoceptor mediating contractions of human prostate to
noradrenaline was characterized by use of a range of competitive and non‐competitive …

The present study, investigates the effect of RBx 6198, 2-{3-[4-(2-Isopropoxy-phenyl)-
piperazin-1-yl]-propyl}-3a, 4, 7, 7a-tetrahydro-isoindole-1, 3,-dione, a novel α1-adrenoceptor …

KMD-3213,(−)-(R)-1-(3-hydroxypropyl)-5-[2-[[2-[2-(2, 2, 2-trifluoroethoxy) phenoxy] ethyl]
amino] propyl] indoline-7-carboxamide, is a novel and selective α1A-adrenoceptor …

Norepinephrine (NE) contracts smooth muscle cells within the human lower urinary tract
(LUT)(bladder neck, prostate, and urethra). Receptor distribution and pharmacological …

α1-Adrenoceptor antagonists, originally targeted towards hypertension, are being
increasingly used in the treatment of benign prostatic hyperplasia. The identification of …

The development of α 1a-adrenergic receptor (AR) subtype-selective antagonists is likely to
result in uroselective agents that effectively treat benign prostatic hyperplasia (BPH) …

Benign prostatic hyperplasia (BPH) is highly prevalent in the male population beyond the
age of 60. Impairment of urinary flow due to prostate enlargement gives rise to symptoms of …

PURPOSE: We compared the affinities of a new alpha1-adrenoceptor (AR) antagonist, JTH-
601 with those of several alpha1-AR antagonists in human prostates and arteries …

The α1‐adrenoceptor subtypes mediating contraction of rabbit prostate and hypogastric
artery were pharmacologically characterized using an isolated organ bath technique. The …

Purpose: To localize the mRNAs and receptor binding sites for the alpha sub 1a/A,
alpha1b/B and alpha1d/D-adrenoceptor (AR) subtypes in the rat, monkey and human …