Background: We previously reported novel quinuclidinone analogs that showed both
additive and synergistic cytotoxicity in lung cancer cells. We aimed at understanding the …

Based on the scaffolds of caffeic acid phenethyl ester (CAPE) as well as bioactive lactone-
containing compounds, 6-acrylic phenethyl ester-2-pyranone derivatives were synthesized …

Thirteen anthraquinone derivatives 5–17 including two 3-(3-alkylaminopropoxy)-9, 10-
anthraquinone (NHA) derivatives 5 and 6, and 11 1-hydroxy-3-(3-alkylaminopropoxy)-9, 10 …

Breast cancer is the second most common type of cancer after lung cancer and the fifth most
common cause of cancer death. Several structural classes of compounds were discovered …

Azaphenothiazines containing the quinoline ring, 8–10-substituted 6 H-quinobenzothiazines
and 6 H-diquinothiazine were transformed into new 6-propargyl and 6-dialkylaminobutynyl …

Several drugs of aziridinylbenzoquinone analogs have undergone clinical trials as potential
antitumor drugs. These bioreductive compounds are designed to kill tumor cells …

Herein are reported the synthesis and anticancer activity against the human breast cancer
cell line MCF-7 of a series of substituted (RS)-9-(2, 3-dihydro-1, 4-benzoxathiin-2-ylmethyl) …

A series of novel N-(2-arylethyl) isoquinoline derivatives were designed, synthesized and
evaluated for their anti-cancer activities. Among these analogs, compound 9a exhibited the …

Investigation on designed polyaminoanthraquinones revealed that the anthraquinones
bearing triamine motifs are generally more potent than their counterparts with diamine or …

A series of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety were
synthesized and evaluated for their in vitro cytotoxic activity against five cancer cell lines (HT …