Two series of simplified analogs of the ecteinascidin–saframycin type alkaloids were
prepared from l-DOPA. Their in vitro antitumor activity was tested against three human …

F HN O NH OHN HO HN Page 1 The fight against the ocular cancer By Edigles Guedes
December 3, 2022 Abstract. We suggest the use of the molecule (6S)-6-((3-fluoro-1,2,3,4-tetrahydroquinolin-8-yl)amino)-1,3,2,4-dioxadiazinan-5-ol …

Purpose Budesonide (Bud) is a nonhalogenated glucocorticoid with high anti-inflammatory
potency and low systemic side effects. However, the poor water solubility of Bud affects its …

Twelve epoxy and hydroxydiosgenin derivatives (DI-1${\sim} $ DI-12) were synthesized from
diosgenin (25 (R)-5-spirosten-3${\beta} $-ol). Diosgenin was epoxidized with m …

A series of substituted derivatives containing the 1, 4-benzodioxine or pyrrole nucleus are
described. All the newly synthesized compounds were examined for their in vitro and in vivo …

The coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic
acid with meta or para substituted carboxylated malachite green analogs gave conjugates …

Background: For the last two decades, diterpenoid isosteviol and its derivatives have gained
significant attention for novel chemical transformation in the drug discovery field. Results: An …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
34962827&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Oleuropein is a glucosylated seco-iridoid present in olive fruits and leaves. Due to its broad
spectrum of biological activities, including anticancer properties, oleuropein has attracted …

Different strategies are presented to conjugate a fluorescein moiety to 9-and 10-
hydroxystearic acids (HSAs). 5-Amino-fluorescein (5-AF) was used as a starting reagent …