Objective We performed a review of studies of fluticasone propionate (FP)/salmeterol
(SAL)(combination inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA)) in patients …

Background: COPD is an inflammatory disorder characterised by chronic airflow limitation,
but the extent to which airway inflammation is related to functional abnormalities is still …

BACKGROUND: Inhaled corticosteroids are effective in suppressing a chronic cough without
asthma associated with sputum eosinophilia. OBJECTIVE: To investigate the inflammatory …

COPD is an obstructive airway disorder characterized by a slowly progressive and
irreversible decrease in FEV1 (1, 2, 7). FEV1 decreases are caused by a narrowing of …

The pathological hallmarks of chronic obstructive pulmonary disease (COPD) are
inflammation of the small airways (bronchiolitis) and destruction of lung parenchyma …

Rationale: Post hoc analyses suggest that blood eosinophils have potential as a predictive
biomarker of inhaled corticosteroid efficacy in the management of chronic obstructive …

Reduction of the future risk of exacerbations represents one of the major aims in the
management of chronic obstructive pulmonary disease (COPD)(1). Although inhaled …

Evidence suggests that eosinophilic airway inflammation is important in the pathogenesis of
severe chronic obstructive pulmonary disease (COPD) exacerbations. The present authors …

Airway inflammation in severe asthma is not well characterized but may involve neutrophils.
We have compared induced sputum profiles in patients with asthma of varying severity and …

Endogenously released nitric oxide (NO) has been detected in the exhaled air of humans.
Exhaled NO (NOexh) levels have been significantly increased in patients with inflammatory …