Oxycholesterols (OS) are formed from cholesterol or its immediate precursors by enzymatic
or free radical action in vivo, or they may be derived from food. OS exhibit a wide spectrum of …

Oxysterols are oxidized species of cholesterol coming from exogenous (eg dietary) and
endogenous (in vivo) sources. They play critical roles in normal physiologic functions such …

Endothelial dysfunction is a key early step in atherosclerosis. 25-Hydroxycholesterol (25-
OHC) is found in atherosclerotic lesions. However, whether 25-OHC promotes …

Direct translation of findings achieved in experimental cell or animal models to humans is
quite a difficult task. We focused here only on the epidemiological and ex vivo human …

The nuclear receptor peroxisome proliferator-activated receptors (PPARs) are important in
regulating lipid metabolism and inflammatory responses in macrophages. Activation of …

Oxysterols, or cholesterol oxidation products, are oxygenated derivatives of cholesterol
which are formed endogenously during the biosynthesis of bile acids and steroid hormones …

The aim of this study was to verify the hypothesis that β-carotene may prevent 7-
ketocholesterol (7-KC)-induced apoptosis in human macrophages. Therefore, THP-1 …

To investigate the proinflammatory potential of cholesterol and cholesterol oxidation
products (oxysterols), which are present in oxidized low-density lipoproteins, foam cells, and …

Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is
vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis …

BACKGROUND & AIMS: Non-alcoholic steatohepatitis is characterized by hepatic steatosis
with inflammation. Although steatosis is benign and reversible, inflammation can increase …