In this article we consider the mechanisms by which the calcium-sensing receptor (CaSR)
induces its cellular responses via the control (activation or inhibition) of signaling pathways …

The calcium (Ca2+)-sensing receptor (CaR) belongs to family C of the G-protein coupled
receptors (GPCRs). The receptor is activated by physiological levels of Ca2+ (and Mg2+) …

The calcium-sensing receptor (CaR), a seven-transmembrane domain receptor belonging to
the G protein-coupled receptor family, is responsible for calcium-mediated signalling …

Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment
of secondary hyperparathyroidism focused on the development of ring constrained …

The extracellular calcium-sensing receptor (CaR), a G protein-coupled receptor that resides
on the parathyroid cell surface negatively regulates secretion of parathyroid hormone (PTH) …

The calcium sensing receptor (CaSR) is expressed in cells secreting calcium-regulating
hormones, in cells involved in calcium transport and in many other tissues, with an as yet not …

Cinacalcet HCl (AMG 073) is an investigational oral calcimimetic drug currently being
evaluated for the treatment of primary and secondary hyperparathyroidism (HPT) …

Bone is intimately involved in systemic mineral ion homeostasis by virtue of its interplay with
parathyroid gland and kidney [1]. The extracellular calcium ion concentration (Cao 2+) in a …

The demonstration of the calcium sensing receptor (CaSR) on the parathyroid glands cell
membranes shed new light on the way serum calcium concentration stimulates or …